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Targeted delivery of 2-PAM to the brain using cationic liposomes modified with lipid-like surfactants for the treatment of acute organophosphorus poisoning.

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Title: Targeted delivery of 2-PAM to the brain using cationic liposomes modified with lipid-like surfactants for the treatment of acute organophosphorus poisoning.
Authors: Kuznetsova DA; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., 420088, Kazan, Russia. Electronic address: Dashyna111@mail.ru., Kuznetsov DM; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., 420088, Kazan, Russia., Gaynanova GA; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., 420088, Kazan, Russia., Zueva IV; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., 420088, Kazan, Russia., Babaev VM; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., 420088, Kazan, Russia., Voloshina AD; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., 420088, Kazan, Russia., Sibgatullina GV; Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center, Russian Academy of Sciences, 2/31 Lobachevsky str., Kazan, 420111, Russia., Petrov KA; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., 420088, Kazan, Russia., Zakharova LY; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., 420088, Kazan, Russia., Sinyashin OG; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., 420088, Kazan, Russia.
Source: Chemico-biological interactions [Chem Biol Interact] 2025 Oct 22; Vol. 420, pp. 111678. Date of Electronic Publication: 2025 Jul 28.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE
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  Data: Targeted delivery of 2-PAM to the brain using cationic liposomes modified with lipid-like surfactants for the treatment of acute organophosphorus poisoning.
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  Data: <searchLink fieldCode="AU" term="%22Kuznetsova+DA%22">Kuznetsova DA</searchLink>; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., 420088, Kazan, Russia. Electronic address: Dashyna111@mail.ru.<br /><searchLink fieldCode="AU" term="%22Kuznetsov+DM%22">Kuznetsov DM</searchLink>; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., 420088, Kazan, Russia.<br /><searchLink fieldCode="AU" term="%22Gaynanova+GA%22">Gaynanova GA</searchLink>; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., 420088, Kazan, Russia.<br /><searchLink fieldCode="AU" term="%22Zueva+IV%22">Zueva IV</searchLink>; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., 420088, Kazan, Russia.<br /><searchLink fieldCode="AU" term="%22Babaev+VM%22">Babaev VM</searchLink>; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., 420088, Kazan, Russia.<br /><searchLink fieldCode="AU" term="%22Voloshina+AD%22">Voloshina AD</searchLink>; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., 420088, Kazan, Russia.<br /><searchLink fieldCode="AU" term="%22Sibgatullina+GV%22">Sibgatullina GV</searchLink>; Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center, Russian Academy of Sciences, 2/31 Lobachevsky str., Kazan, 420111, Russia.<br /><searchLink fieldCode="AU" term="%22Petrov+KA%22">Petrov KA</searchLink>; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., 420088, Kazan, Russia.<br /><searchLink fieldCode="AU" term="%22Zakharova+LY%22">Zakharova LY</searchLink>; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., 420088, Kazan, Russia.<br /><searchLink fieldCode="AU" term="%22Sinyashin+OG%22">Sinyashin OG</searchLink>; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., 420088, Kazan, Russia.
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  Data: <searchLink fieldCode="JN" term="%220227276%22">Chemico-biological interactions</searchLink> [Chem Biol Interact] 2025 Oct 22; Vol. 420, pp. 111678. <i>Date of Electronic Publication: </i>2025 Jul 28.
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              Text: 2025 Oct 22
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