Engineered L-asparaginase variants with enhanced therapeutic properties to improve treatment of childhood acute lymphatic leukemia.

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Title: Engineered L-asparaginase variants with enhanced therapeutic properties to improve treatment of childhood acute lymphatic leukemia.
Authors: Biswas M; School of Biotechnology, Campus-11, KIIT Deemed to be University, Bhubaneswar, Odisha, India., Sengupta S; School of Biotechnology, Campus-11, KIIT Deemed to be University, Bhubaneswar, Odisha, India., Gandhi KA; Department of Clinical Pharmacology, ACTREC, Tata Memorial Centre, Navi Mumbai, India., Gupta SK; Department of Clinical Pharmacology, ACTREC, Tata Memorial Centre, Navi Mumbai, India.; Homi Bhabha National Institute, Training School Complex, Mumbai, India., Gera PB; Homi Bhabha National Institute, Training School Complex, Mumbai, India.; Department of Pathology, ACTREC, Tata Memorial Centre, Navi Mumbai, India., Nayak BS; Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore (IIT Indore), Simrol, Madhya Pradesh, India., Jagadeb M; School of Biotechnology, Campus-11, KIIT Deemed to be University, Bhubaneswar, Odisha, India., Gota V; Department of Clinical Pharmacology, ACTREC, Tata Memorial Centre, Navi Mumbai, India. vgota@actrec.gov.in.; Homi Bhabha National Institute, Training School Complex, Mumbai, India. vgota@actrec.gov.in., Sonawane A; School of Biotechnology, Campus-11, KIIT Deemed to be University, Bhubaneswar, Odisha, India. asonawane@iiti.ac.in.; Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore (IIT Indore), Simrol, Madhya Pradesh, India. asonawane@iiti.ac.in.
Source: Cancer gene therapy [Cancer Gene Ther] 2025 Oct; Vol. 32 (10), pp. 1062-1075. Date of Electronic Publication: 2025 Jul 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9432230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5500 (Electronic) Linking ISSN: 09291903 NLM ISO Abbreviation: Cancer Gene Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5500
DOI:10.1038/s41417-024-00865-6