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Engineered L-asparaginase variants with enhanced therapeutic properties to improve treatment of childhood acute lymphatic leukemia.

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Title: Engineered L-asparaginase variants with enhanced therapeutic properties to improve treatment of childhood acute lymphatic leukemia.
Authors: Biswas M; School of Biotechnology, Campus-11, KIIT Deemed to be University, Bhubaneswar, Odisha, India., Sengupta S; School of Biotechnology, Campus-11, KIIT Deemed to be University, Bhubaneswar, Odisha, India., Gandhi KA; Department of Clinical Pharmacology, ACTREC, Tata Memorial Centre, Navi Mumbai, India., Gupta SK; Department of Clinical Pharmacology, ACTREC, Tata Memorial Centre, Navi Mumbai, India.; Homi Bhabha National Institute, Training School Complex, Mumbai, India., Gera PB; Homi Bhabha National Institute, Training School Complex, Mumbai, India.; Department of Pathology, ACTREC, Tata Memorial Centre, Navi Mumbai, India., Nayak BS; Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore (IIT Indore), Simrol, Madhya Pradesh, India., Jagadeb M; School of Biotechnology, Campus-11, KIIT Deemed to be University, Bhubaneswar, Odisha, India., Gota V; Department of Clinical Pharmacology, ACTREC, Tata Memorial Centre, Navi Mumbai, India. vgota@actrec.gov.in.; Homi Bhabha National Institute, Training School Complex, Mumbai, India. vgota@actrec.gov.in., Sonawane A; School of Biotechnology, Campus-11, KIIT Deemed to be University, Bhubaneswar, Odisha, India. asonawane@iiti.ac.in.; Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore (IIT Indore), Simrol, Madhya Pradesh, India. asonawane@iiti.ac.in.
Source: Cancer gene therapy [Cancer Gene Ther] 2025 Oct; Vol. 32 (10), pp. 1062-1075. Date of Electronic Publication: 2025 Jul 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9432230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5500 (Electronic) Linking ISSN: 09291903 NLM ISO Abbreviation: Cancer Gene Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Engineered L-asparaginase variants with enhanced therapeutic properties to improve treatment of childhood acute lymphatic leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Biswas+M%22">Biswas M</searchLink>; School of Biotechnology, Campus-11, KIIT Deemed to be University, Bhubaneswar, Odisha, India.<br /><searchLink fieldCode="AU" term="%22Sengupta+S%22">Sengupta S</searchLink>; School of Biotechnology, Campus-11, KIIT Deemed to be University, Bhubaneswar, Odisha, India.<br /><searchLink fieldCode="AU" term="%22Gandhi+KA%22">Gandhi KA</searchLink>; Department of Clinical Pharmacology, ACTREC, Tata Memorial Centre, Navi Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Gupta+SK%22">Gupta SK</searchLink>; Department of Clinical Pharmacology, ACTREC, Tata Memorial Centre, Navi Mumbai, India.; Homi Bhabha National Institute, Training School Complex, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Gera+PB%22">Gera PB</searchLink>; Homi Bhabha National Institute, Training School Complex, Mumbai, India.; Department of Pathology, ACTREC, Tata Memorial Centre, Navi Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Nayak+BS%22">Nayak BS</searchLink>; Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore (IIT Indore), Simrol, Madhya Pradesh, India.<br /><searchLink fieldCode="AU" term="%22Jagadeb+M%22">Jagadeb M</searchLink>; School of Biotechnology, Campus-11, KIIT Deemed to be University, Bhubaneswar, Odisha, India.<br /><searchLink fieldCode="AU" term="%22Gota+V%22">Gota V</searchLink>; Department of Clinical Pharmacology, ACTREC, Tata Memorial Centre, Navi Mumbai, India. vgota@actrec.gov.in.; Homi Bhabha National Institute, Training School Complex, Mumbai, India. vgota@actrec.gov.in.<br /><searchLink fieldCode="AU" term="%22Sonawane+A%22">Sonawane A</searchLink>; School of Biotechnology, Campus-11, KIIT Deemed to be University, Bhubaneswar, Odisha, India. asonawane@iiti.ac.in.; Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore (IIT Indore), Simrol, Madhya Pradesh, India. asonawane@iiti.ac.in.
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  Data: <searchLink fieldCode="JN" term="%229432230%22">Cancer gene therapy</searchLink> [Cancer Gene Ther] 2025 Oct; Vol. 32 (10), pp. 1062-1075. <i>Date of Electronic Publication: </i>2025 Jul 30.
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        Value: 10.1038/s41417-024-00865-6
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              Text: 2025 Oct
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