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SuFEx-based antitubercular compound irreversibly inhibits Pks13.

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Title: SuFEx-based antitubercular compound irreversibly inhibits Pks13.
Authors: Krieger IV; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA., Sukheja P; Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research, La Jolla, CA, USA., Yang B; Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research, La Jolla, CA, USA., Tang S; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA., Selle D; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA., Woods A; Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research, La Jolla, CA, USA., Engelhart C; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA., Kumar P; New Jersey Medical School Division of Infectious Disease, Department of Medicine, Rutgers University, Newark, NJ, USA.; Ruy V. Lourenco Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University, Newark, NJ, USA., Harbut MB; Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research, La Jolla, CA, USA., Liu D; Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research, La Jolla, CA, USA., Tsuda B; Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research, La Jolla, CA, USA., Qin B; Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research, La Jolla, CA, USA., Bare GAL; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Li G; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Chi V; Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research, La Jolla, CA, USA., Gambacurta J; Trudeau Institute, Saranac Lake, NY, USA., Hvizdos J; Trudeau Institute, Saranac Lake, NY, USA., Reagan M; Trudeau Institute, Saranac Lake, NY, USA., Jones IL; Trudeau Institute, Saranac Lake, NY, USA., Massoudi LM; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA., Woolhiser LK; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA., Cascioferro A; Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research, La Jolla, CA, USA., Kundrick E; Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research, La Jolla, CA, USA., Singh P; New Jersey Medical School Division of Infectious Disease, Department of Medicine, Rutgers University, Newark, NJ, USA.; Ruy V. Lourenco Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University, Newark, NJ, USA., Reiley W; Trudeau Institute, Saranac Lake, NY, USA., Ioerger TR; Department of Computer Science, Texas A&M University, College Station, TX, USA., Kandula DR; AB Sciex LLC, Framingham, MA, USA., McCabe JW; AB Sciex LLC, Framingham, MA, USA., Guo T; Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai, China., Alland D; New Jersey Medical School Division of Infectious Disease, Department of Medicine, Rutgers University, Newark, NJ, USA.; Ruy V. Lourenco Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University, Newark, NJ, USA., Boshoff HI; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA., Schnappinger D; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA., Robertson GT; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA., Mdluli K; Gates Medical Research Institute, Cambridge, MA, USA., Lee KJ; Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research, La Jolla, CA, USA., Dong J; Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai, China., Li S; Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research, La Jolla, CA, USA., Schultz PG; Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research, La Jolla, CA, USA.; The Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA., Joseph SB; Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research, La Jolla, CA, USA., Love MS; Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research, La Jolla, CA, USA., Sharpless KB; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Petrassi HM; Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research, La Jolla, CA, USA., Chatterjee AK; Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research, La Jolla, CA, USA., Sacchettini JC; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA. sacchett@tamu.edu., McNamara CW; Calibr-Skaggs Institute for Innovative Medicines, A Division of Scripps Research, La Jolla, CA, USA. cmcnamara@scripps.edu.
Source: Nature [Nature] 2025 Sep; Vol. 645 (8081), pp. 755-763. Date of Electronic Publication: 2025 Jul 30.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: SuFEx-based antitubercular compound irreversibly inhibits Pks13.
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