SCoTCH-seq reveals that 5-hydroxymethylcytosine encodes regulatory information across DNA strands. - Hardwick JS; Dhir S; Kirchner A; Simeone A; Flynn SM; Edgerton JM; de Cesaris Araujo Tavares R; Esain-Garcia I; Tannahill D; Golder P; Monahan JM; Gosal WS; et al. (Proceedings of the National Academy of Sciences of the United States of America, 2025)