Hormonal factors predictive of fertility in patients with breast cancer interrupting adjuvant endocrine therapy to attempt pregnancy in POSITIVE trial.

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Title: Hormonal factors predictive of fertility in patients with breast cancer interrupting adjuvant endocrine therapy to attempt pregnancy in POSITIVE trial.
Authors: Demeestere I; Research Laboratory on Human Reproduction, Université Libre de Bruxelles (ULB), Brussels, Belgium; Gynecology and Obstetrics Department, Fertility Clinic, H.U.B Erasme Hospital, Brussels, Belgium. Electronic address: Isabelle.demeestere@ulb.be., Niman SM; International Breast Cancer Study Group Statistical Center, Boston, MA, USA; Department of Data Science, Division of Biostatistics, Dana-Farber Cancer Institute, Boston, MA, USA., Partridge AH; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Diego DS; Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA., Kammler R; Translational Research Coordination, International Breast Cancer Study Group, a Division of ETOP IBCSG Partners Foundation, Bern, Switzerland., Ruggeri M; Program for Young Patients, International Breast Cancer Study Group, a Division of ETOP IBCSG Partners Foundation, Bern, Switzerland., Colleoni M; Division of Medical Senology, IEO, European Institute of Oncology, IRCCS, Milan, Italy., Shimizu C; Department of Breast and Medical Oncology, National Center for Global Health and Medicine, Tokyo, Japan., Saura C; Vall D'Hebron University Hospital, Vall D'Hebron Institute of Oncology, Barcelona, Spain; SOLTI Breast Cancer Research Group, Barcelona, Spain., Gelmon KA; BC Cancer Vancouver Centre, University of British Columbia, Vancouver, BC, Canada., Saetersdal AB; Breast Cancer Unit, Department of Oncology, Division of Cancer Medicine, Oslo University Hospital, Oslo, Norway., Kroep JR; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands; Dutch Breast Cancer Research Group (BOOG), the Netherlands., Mailliez A; Department of Medical Oncology, Breast Cancer Unit, Centre Oscar Lambret, Lille, France., Amant F; Department of Oncology, KU Leuven and Leuven Cancer Institute, Leuven, Belgium; Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium; Antoni van Leeuwenhoek-Netherlands Cancer Institute, Amsterdam, the Netherlands., Ruız-Borrego M; GEICAM Spanish Breast Cancer Group, Madrid, Spain; Hospital Virgen Del Rocio Sevilla, Sevilla, Spain., Lee JE; Breast Division, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Clinical Research and Evaluation, SAIHST, Sungkyunkwan University, Seoul, South Korea., Kataoka A; Breast Oncology Center, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan., Walshe JM; Cancer Trials Ireland, Dublin, Ireland; Department of Medical Oncology, St. Vincent's University Hospital, Dublin, Ireland., Takei J; St Luke's International Hospital, Breast Center, Tokyo, Japan., Borstnar S; Division of Medical Oncology, Institute of Oncology, Ljubljana, Slovenia., Borges VF; Division of Medical Oncology, Department of Medicine, University of Colorado Cancer Center, Aurora, CO, USA., Saunders C; Department of Surgery, University of Melbourne, Melbourne, VIC, Australia; Royal Melbourne Hospital, Melbourne, VIC, Australia., Susnjar S; Department of Medical Oncology, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia., Bjelic-Radisic V; Breast Unit, Helios University Hospital Wuppertal, University Witten/Herdecke, Wuppertal, Germany; Austrian Breast and Colorectal Study Group (ABCSG), Austria., Cardoso F; Breast Unit, Champalimaud Foundation and Advanced Breast Cancer (ABC) Global Alliance, Lisbon, Portugal., Meisel JL; Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA., Kawwass JF; Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA., Spanic T; Europa Donna, Ljubljana, Slovenia and Europa Donna - The European Breast Cancer Coalition, Milan, Italy., El-Abed S; Breast International Group, Brussels, Belgium., Piccart M; Breast International Group, Brussels, Belgium; Institut Jules Bordet and Université Libre de Bruxelles, Brussels, Belgium., Korde LA; Breast and Melanoma Therapeutics, Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD, USA., Goldhirsch A; International Breast Cancer Study Group, Division of ETOP IBCSG Partners Foundation, Bern, Switzerland; IEO, European Institute of Oncology, IRCCS, Milan, Italy., Gelber RD; International Breast Cancer Study Group Statistical Center, Boston, MA, USA; Department of Data Science, Division of Biostatistics, Dana-Farber Cancer Institute, Boston, MA, USA; Frontier Science Foundation, Boston, MA, USA; Harvard TH Chan School of Public Health, Boston, MA, USA., Pagani O; Geneva University Hospitals, Geneva, Switzerland; Lugano University, Lugano, Switzerland; Swiss Group for Clinical Cancer Research (SAKK), Bern, Switzerland., Azim HA Jr; Cairo Cure Oncology Center, Cairo, Egypt., Peccatori FA; Fertility and Procreation Unit, Gynecologic Oncology Program, European Institute of Oncology IRCCS, Milan, Italy.
Corporate Authors: International Breast Cancer Study Group and the POSITIVE Trial Collaborators
Source: Breast (Edinburgh, Scotland) [Breast] 2025 Oct; Vol. 83, pp. 104547. Date of Electronic Publication: 2025 Jul 26.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9213011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3080 (Electronic) Linking ISSN: 09609776 NLM ISO Abbreviation: Breast Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Hormonal factors predictive of fertility in patients with breast cancer interrupting adjuvant endocrine therapy to attempt pregnancy in POSITIVE trial.
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  Data: <searchLink fieldCode="AU" term="%22Demeestere+I%22">Demeestere I</searchLink>; Research Laboratory on Human Reproduction, Université Libre de Bruxelles (ULB), Brussels, Belgium; Gynecology and Obstetrics Department, Fertility Clinic, H.U.B Erasme Hospital, Brussels, Belgium. Electronic address: Isabelle.demeestere@ulb.be.<br /><searchLink fieldCode="AU" term="%22Niman+SM%22">Niman SM</searchLink>; International Breast Cancer Study Group Statistical Center, Boston, MA, USA; Department of Data Science, Division of Biostatistics, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Partridge+AH%22">Partridge AH</searchLink>; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Diego+DS%22">Diego DS</searchLink>; Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Kammler+R%22">Kammler R</searchLink>; Translational Research Coordination, International Breast Cancer Study Group, a Division of ETOP IBCSG Partners Foundation, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ruggeri+M%22">Ruggeri M</searchLink>; Program for Young Patients, International Breast Cancer Study Group, a Division of ETOP IBCSG Partners Foundation, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Colleoni+M%22">Colleoni M</searchLink>; Division of Medical Senology, IEO, European Institute of Oncology, IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Shimizu+C%22">Shimizu C</searchLink>; Department of Breast and Medical Oncology, National Center for Global Health and Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Saura+C%22">Saura C</searchLink>; Vall D'Hebron University Hospital, Vall D'Hebron Institute of Oncology, Barcelona, Spain; SOLTI Breast Cancer Research Group, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Gelmon+KA%22">Gelmon KA</searchLink>; BC Cancer Vancouver Centre, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Saetersdal+AB%22">Saetersdal AB</searchLink>; Breast Cancer Unit, Department of Oncology, Division of Cancer Medicine, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Kroep+JR%22">Kroep JR</searchLink>; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands; Dutch Breast Cancer Research Group (BOOG), the Netherlands.<br /><searchLink fieldCode="AU" term="%22Mailliez+A%22">Mailliez A</searchLink>; Department of Medical Oncology, Breast Cancer Unit, Centre Oscar Lambret, Lille, France.<br /><searchLink fieldCode="AU" term="%22Amant+F%22">Amant F</searchLink>; Department of Oncology, KU Leuven and Leuven Cancer Institute, Leuven, Belgium; Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium; Antoni van Leeuwenhoek-Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ruız-Borrego+M%22">Ruız-Borrego M</searchLink>; GEICAM Spanish Breast Cancer Group, Madrid, Spain; Hospital Virgen Del Rocio Sevilla, Sevilla, Spain.<br /><searchLink fieldCode="AU" term="%22Lee+JE%22">Lee JE</searchLink>; Breast Division, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Clinical Research and Evaluation, SAIHST, Sungkyunkwan University, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kataoka+A%22">Kataoka A</searchLink>; Breast Oncology Center, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Walshe+JM%22">Walshe JM</searchLink>; Cancer Trials Ireland, Dublin, Ireland; Department of Medical Oncology, St. Vincent's University Hospital, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Takei+J%22">Takei J</searchLink>; St Luke's International Hospital, Breast Center, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Borstnar+S%22">Borstnar S</searchLink>; Division of Medical Oncology, Institute of Oncology, Ljubljana, Slovenia.<br /><searchLink fieldCode="AU" term="%22Borges+VF%22">Borges VF</searchLink>; Division of Medical Oncology, Department of Medicine, University of Colorado Cancer Center, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Saunders+C%22">Saunders C</searchLink>; Department of Surgery, University of Melbourne, Melbourne, VIC, Australia; Royal Melbourne Hospital, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Susnjar+S%22">Susnjar S</searchLink>; Department of Medical Oncology, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.<br /><searchLink fieldCode="AU" term="%22Bjelic-Radisic+V%22">Bjelic-Radisic V</searchLink>; Breast Unit, Helios University Hospital Wuppertal, University Witten/Herdecke, Wuppertal, Germany; Austrian Breast and Colorectal Study Group (ABCSG), Austria.<br /><searchLink fieldCode="AU" term="%22Cardoso+F%22">Cardoso F</searchLink>; Breast Unit, Champalimaud Foundation and Advanced Breast Cancer (ABC) Global Alliance, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Meisel+JL%22">Meisel JL</searchLink>; Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Kawwass+JF%22">Kawwass JF</searchLink>; Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Spanic+T%22">Spanic T</searchLink>; Europa Donna, Ljubljana, Slovenia and Europa Donna - The European Breast Cancer Coalition, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22El-Abed+S%22">El-Abed S</searchLink>; Breast International Group, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Piccart+M%22">Piccart M</searchLink>; Breast International Group, Brussels, Belgium; Institut Jules Bordet and Université Libre de Bruxelles, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Korde+LA%22">Korde LA</searchLink>; Breast and Melanoma Therapeutics, Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Goldhirsch+A%22">Goldhirsch A</searchLink>; International Breast Cancer Study Group, Division of ETOP IBCSG Partners Foundation, Bern, Switzerland; IEO, European Institute of Oncology, IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Gelber+RD%22">Gelber RD</searchLink>; International Breast Cancer Study Group Statistical Center, Boston, MA, USA; Department of Data Science, Division of Biostatistics, Dana-Farber Cancer Institute, Boston, MA, USA; Frontier Science Foundation, Boston, MA, USA; Harvard TH Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pagani+O%22">Pagani O</searchLink>; Geneva University Hospitals, Geneva, Switzerland; Lugano University, Lugano, Switzerland; Swiss Group for Clinical Cancer Research (SAKK), Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Azim+HA+Jr%22">Azim HA Jr</searchLink>; Cairo Cure Oncology Center, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Peccatori+FA%22">Peccatori FA</searchLink>; Fertility and Procreation Unit, Gynecologic Oncology Program, European Institute of Oncology IRCCS, Milan, Italy.
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  Data: <searchLink fieldCode="JN" term="%229213011%22">Breast (Edinburgh, Scotland)</searchLink> [Breast] 2025 Oct; Vol. 83, pp. 104547. <i>Date of Electronic Publication: </i>2025 Jul 26.
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