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Identification of amino acid residues in polymerase PB2 responsible for differential replication and pathogenicity of avian influenza virus H5N1 isolated from human and cattle in Texas, US.

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Title: Identification of amino acid residues in polymerase PB2 responsible for differential replication and pathogenicity of avian influenza virus H5N1 isolated from human and cattle in Texas, US.
Authors: Bayoumi M; Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) Programs, Texas Biomedical Research Institute, San Antonio, TX, USA.; Virology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Barre RS; Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) Programs, Texas Biomedical Research Institute, San Antonio, TX, USA., Escobedo RA; Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) Programs, Texas Biomedical Research Institute, San Antonio, TX, USA., Shivanna V; Southwest National Primate Research Center at the Texas Biomedical Research Institute, San Antonio, TX, USA., Jackson N; Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) Programs, Texas Biomedical Research Institute, San Antonio, TX, USA., Ye C; Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) Programs, Texas Biomedical Research Institute, San Antonio, TX, USA., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mostafa A; Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) Programs, Texas Biomedical Research Institute, San Antonio, TX, USA.; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt., Martinez-Sobrido L; Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) Programs, Texas Biomedical Research Institute, San Antonio, TX, USA.
Source: Emerging microbes & infections [Emerg Microbes Infect] 2025 Dec; Vol. 14 (1), pp. 2542247. Date of Electronic Publication: 2025 Aug 20.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101594885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2222-1751 (Electronic) Linking ISSN: 22221751 NLM ISO Abbreviation: Emerg Microbes Infect Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Identification of amino acid residues in polymerase PB2 responsible for differential replication and pathogenicity of avian influenza virus H5N1 isolated from human and cattle in Texas, US.
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  Data: <searchLink fieldCode="AU" term="%22Bayoumi+M%22">Bayoumi M</searchLink>; Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) Programs, Texas Biomedical Research Institute, San Antonio, TX, USA.; Virology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.<br /><searchLink fieldCode="AU" term="%22Barre+RS%22">Barre RS</searchLink>; Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) Programs, Texas Biomedical Research Institute, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Escobedo+RA%22">Escobedo RA</searchLink>; Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) Programs, Texas Biomedical Research Institute, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Shivanna+V%22">Shivanna V</searchLink>; Southwest National Primate Research Center at the Texas Biomedical Research Institute, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Jackson+N%22">Jackson N</searchLink>; Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) Programs, Texas Biomedical Research Institute, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ye+C%22">Ye C</searchLink>; Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) Programs, Texas Biomedical Research Institute, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22García-Sastre+A%22">García-Sastre A</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Mostafa+A%22">Mostafa A</searchLink>; Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) Programs, Texas Biomedical Research Institute, San Antonio, TX, USA.; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt.<br /><searchLink fieldCode="AU" term="%22Martinez-Sobrido+L%22">Martinez-Sobrido L</searchLink>; Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) Programs, Texas Biomedical Research Institute, San Antonio, TX, USA.
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