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Molecular characterization of the archaic HLA-B∗73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2.

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Title: Molecular characterization of the archaic HLA-B∗73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2.
Authors: Ross P; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA; Committee on Genetics, Genomics and Systems Biology, The University of Chicago, Chicago, Illinois, USA., Hilton HG; Department of Structural Biology, School of Medicine, Stanford University, Stanford, USA; Department of Microbiology & Immunology, School of Medicine, Stanford University, Stanford, USA., Lodwick J; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA., Slezak T; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA., Guethlein LA; Department of Structural Biology, School of Medicine, Stanford University, Stanford, USA; Department of Microbiology & Immunology, School of Medicine, Stanford University, Stanford, USA., McMurtrey CP; Department of Microbiology & Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA., Han AS; Department of Structural Biology, School of Medicine, Stanford University, Stanford, USA; Department of Microbiology & Immunology, School of Medicine, Stanford University, Stanford, USA., Nielsen M; Department of Health Technology, Technical University of Denmark, Kgs. Lyngby, Denmark., Yong D; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA., Dulberger CL; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA., Nolan KT; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA., Roy S; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA., Castro CD; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA., Hildebrand WH; Department of Microbiology & Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA., Zhao M; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA., Kossiakoff A; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA., Parham P; Department of Structural Biology, School of Medicine, Stanford University, Stanford, USA; Department of Microbiology & Immunology, School of Medicine, Stanford University, Stanford, USA. Electronic address: peropa@stanford.edu., Adams EJ; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA; Committee on Genetics, Genomics and Systems Biology, The University of Chicago, Chicago, Illinois, USA. Electronic address: ejadams@uchicago.edu.
Source: The Journal of biological chemistry [J Biol Chem] 2025 Sep; Vol. 301 (9), pp. 110542. Date of Electronic Publication: 2025 Jul 30.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
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  Data: Molecular characterization of the archaic HLA-B∗73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2.
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  Data: <searchLink fieldCode="AU" term="%22Ross+P%22">Ross P</searchLink>; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA; Committee on Genetics, Genomics and Systems Biology, The University of Chicago, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Hilton+HG%22">Hilton HG</searchLink>; Department of Structural Biology, School of Medicine, Stanford University, Stanford, USA; Department of Microbiology & Immunology, School of Medicine, Stanford University, Stanford, USA.<br /><searchLink fieldCode="AU" term="%22Lodwick+J%22">Lodwick J</searchLink>; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Slezak+T%22">Slezak T</searchLink>; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Guethlein+LA%22">Guethlein LA</searchLink>; Department of Structural Biology, School of Medicine, Stanford University, Stanford, USA; Department of Microbiology & Immunology, School of Medicine, Stanford University, Stanford, USA.<br /><searchLink fieldCode="AU" term="%22McMurtrey+CP%22">McMurtrey CP</searchLink>; Department of Microbiology & Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Han+AS%22">Han AS</searchLink>; Department of Structural Biology, School of Medicine, Stanford University, Stanford, USA; Department of Microbiology & Immunology, School of Medicine, Stanford University, Stanford, USA.<br /><searchLink fieldCode="AU" term="%22Nielsen+M%22">Nielsen M</searchLink>; Department of Health Technology, Technical University of Denmark, Kgs. Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Yong+D%22">Yong D</searchLink>; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Dulberger+CL%22">Dulberger CL</searchLink>; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Nolan+KT%22">Nolan KT</searchLink>; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Roy+S%22">Roy S</searchLink>; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Castro+CD%22">Castro CD</searchLink>; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Hildebrand+WH%22">Hildebrand WH</searchLink>; Department of Microbiology & Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+M%22">Zhao M</searchLink>; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Kossiakoff+A%22">Kossiakoff A</searchLink>; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Parham+P%22">Parham P</searchLink>; Department of Structural Biology, School of Medicine, Stanford University, Stanford, USA; Department of Microbiology & Immunology, School of Medicine, Stanford University, Stanford, USA. Electronic address: peropa@stanford.edu.<br /><searchLink fieldCode="AU" term="%22Adams+EJ%22">Adams EJ</searchLink>; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA; Committee on Genetics, Genomics and Systems Biology, The University of Chicago, Chicago, Illinois, USA. Electronic address: ejadams@uchicago.edu.
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  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2025 Sep; Vol. 301 (9), pp. 110542. <i>Date of Electronic Publication: </i>2025 Jul 30.
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