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Trim21 deficiency alleviates osteoporosis by inhibiting osteoclast differentiation through regulating Txnip.

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Title: Trim21 deficiency alleviates osteoporosis by inhibiting osteoclast differentiation through regulating Txnip.
Authors: Peng YC; Department of Bone and Joint Surgery, the First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, Guangdong, 510630, People's Republic of China., Ye YS; Department of Bone and Joint Surgery, the First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, Guangdong, 510630, People's Republic of China.; Department of Orthopedics, Dongguan Hospital of Traditional Chinese Medicine, Dongguan, Guangdong, 523000, People's Republic of China., Hu QX; Department of Bone and Joint Surgery, the First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, Guangdong, 510630, People's Republic of China., Hao ZQ; Department of Bone and Joint Surgery, the First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, Guangdong, 510630, People's Republic of China., Li ZY; Department of Bone and Joint Surgery, the First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, Guangdong, 510630, People's Republic of China., Jiang LY; Department of Bone and Joint Surgery, the First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, Guangdong, 510630, People's Republic of China., Peng HR; Department of Bone and Joint Surgery, the First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, Guangdong, 510630, People's Republic of China., Liu RX; Department of Orthopedics, The First Affiliated Hospital of Guangzhou Medical University, Guangdong Key Laboratory of Orthopedic Technology and Implant Materials, Guangzhou Orthopedic Institute, Guangzhou Medical University, Guangzhou, Guangdong, 510120, People's Republic of China. liurixu@gzhmu.edu.cn., Zha ZG; Department of Bone and Joint Surgery, the First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, Guangdong, 510630, People's Republic of China. zhzgg@vip.163.com., Zhang HT; Department of Bone and Joint Surgery, the First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, Guangdong, 510630, People's Republic of China. zhanghuantian@jnu.edu.cn.
Source: Arthritis research & therapy [Arthritis Res Ther] 2025 Aug 01; Vol. 27 (1), pp. 163. Date of Electronic Publication: 2025 Aug 01.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101154438 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-6362 (Electronic) Linking ISSN: 14786354 NLM ISO Abbreviation: Arthritis Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Trim21 deficiency alleviates osteoporosis by inhibiting osteoclast differentiation through regulating Txnip.
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  Data: <searchLink fieldCode="AU" term="%22Peng+YC%22">Peng YC</searchLink>; Department of Bone and Joint Surgery, the First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, Guangdong, 510630, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Ye+YS%22">Ye YS</searchLink>; Department of Bone and Joint Surgery, the First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, Guangdong, 510630, People's Republic of China.; Department of Orthopedics, Dongguan Hospital of Traditional Chinese Medicine, Dongguan, Guangdong, 523000, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Hu+QX%22">Hu QX</searchLink>; Department of Bone and Joint Surgery, the First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, Guangdong, 510630, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Hao+ZQ%22">Hao ZQ</searchLink>; Department of Bone and Joint Surgery, the First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, Guangdong, 510630, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Li+ZY%22">Li ZY</searchLink>; Department of Bone and Joint Surgery, the First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, Guangdong, 510630, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Jiang+LY%22">Jiang LY</searchLink>; Department of Bone and Joint Surgery, the First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, Guangdong, 510630, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Peng+HR%22">Peng HR</searchLink>; Department of Bone and Joint Surgery, the First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, Guangdong, 510630, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Liu+RX%22">Liu RX</searchLink>; Department of Orthopedics, The First Affiliated Hospital of Guangzhou Medical University, Guangdong Key Laboratory of Orthopedic Technology and Implant Materials, Guangzhou Orthopedic Institute, Guangzhou Medical University, Guangzhou, Guangdong, 510120, People's Republic of China. liurixu@gzhmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zha+ZG%22">Zha ZG</searchLink>; Department of Bone and Joint Surgery, the First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, Guangdong, 510630, People's Republic of China. zhzgg@vip.163.com.<br /><searchLink fieldCode="AU" term="%22Zhang+HT%22">Zhang HT</searchLink>; Department of Bone and Joint Surgery, the First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, Guangdong, 510630, People's Republic of China. zhanghuantian@jnu.edu.cn.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101154438 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1478-6362 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214786354%22">14786354 </searchLink><i>NLM ISO Abbreviation: </i>Arthritis Res Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s13075-025-03624-6
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            – D: 01
              M: 08
              Text: 2025 Aug 01
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