Design of soluble Notch agonists that drive T cell development and boost immunity.

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Title: Design of soluble Notch agonists that drive T cell development and boost immunity.
Authors: Mout R; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA., Jing R; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA., Tanaka-Yano M; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA., Egan ED; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Eisenach H; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Kononov MA; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA., Windisch R; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA., Najia MAT; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Tompkins A; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA., Hensch L; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA., Bingham T; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA., Gunage R; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA., Zhao Y; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA., Edman NI; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Medical Scientist Training Program, University of Washington, Seattle, WA 98195, USA., Li C; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Wang D; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA., Schlaeger TM; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA., Zon LI; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Harvard Stem Cell Institute, Boston, MA 02115, USA., North TE; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA., Lendahl U; Department of Cell and Molecular Biology, Karolinska Institutet, 17177 Stockholm, Sweden., Rowe RG; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Baker D; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA., Blacklow SC; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Daley GQ; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address: george_daley@hms.harvard.edu.
Source: Cell [Cell] 2025 Oct 16; Vol. 188 (21), pp. 5980-5994.e28. Date of Electronic Publication: 2025 Aug 01.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4172
DOI:10.1016/j.cell.2025.07.009