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Design of soluble Notch agonists that drive T cell development and boost immunity.

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Title: Design of soluble Notch agonists that drive T cell development and boost immunity.
Authors: Mout R; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA., Jing R; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA., Tanaka-Yano M; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA., Egan ED; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Eisenach H; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Kononov MA; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA., Windisch R; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA., Najia MAT; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Tompkins A; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA., Hensch L; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA., Bingham T; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA., Gunage R; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA., Zhao Y; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA., Edman NI; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Medical Scientist Training Program, University of Washington, Seattle, WA 98195, USA., Li C; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Wang D; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA., Schlaeger TM; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA., Zon LI; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Harvard Stem Cell Institute, Boston, MA 02115, USA., North TE; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA., Lendahl U; Department of Cell and Molecular Biology, Karolinska Institutet, 17177 Stockholm, Sweden., Rowe RG; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Baker D; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA., Blacklow SC; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Daley GQ; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address: george_daley@hms.harvard.edu.
Source: Cell [Cell] 2025 Oct 16; Vol. 188 (21), pp. 5980-5994.e28. Date of Electronic Publication: 2025 Aug 01.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Design of soluble Notch agonists that drive T cell development and boost immunity.
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  Data: <searchLink fieldCode="AU" term="%22Mout+R%22">Mout R</searchLink>; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Jing+R%22">Jing R</searchLink>; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Tanaka-Yano+M%22">Tanaka-Yano M</searchLink>; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Egan+ED%22">Egan ED</searchLink>; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Eisenach+H%22">Eisenach H</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Kononov+MA%22">Kononov MA</searchLink>; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Windisch+R%22">Windisch R</searchLink>; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Najia+MAT%22">Najia MAT</searchLink>; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Tompkins+A%22">Tompkins A</searchLink>; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Hensch+L%22">Hensch L</searchLink>; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Bingham+T%22">Bingham T</searchLink>; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Gunage+R%22">Gunage R</searchLink>; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Edman+NI%22">Edman NI</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Medical Scientist Training Program, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Wang+D%22">Wang D</searchLink>; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Schlaeger+TM%22">Schlaeger TM</searchLink>; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Zon+LI%22">Zon LI</searchLink>; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Harvard Stem Cell Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22North+TE%22">North TE</searchLink>; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Lendahl+U%22">Lendahl U</searchLink>; Department of Cell and Molecular Biology, Karolinska Institutet, 17177 Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Rowe+RG%22">Rowe RG</searchLink>; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Baker+D%22">Baker D</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Blacklow+SC%22">Blacklow SC</searchLink>; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Daley+GQ%22">Daley GQ</searchLink>; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address: george_daley@hms.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%220413066%22">Cell</searchLink> [Cell] 2025 Oct 16; Vol. 188 (21), pp. 5980-5994.e28. <i>Date of Electronic Publication: </i>2025 Aug 01.
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