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Canadian Adaptive Platform Trial of Treatments for COVID in Community Settings (CanTreatCOVID): protocol for a randomised controlled adaptive platform trial of treatments for acute SARS-CoV-2 infection in community settings.

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Title: Canadian Adaptive Platform Trial of Treatments for COVID in Community Settings (CanTreatCOVID): protocol for a randomised controlled adaptive platform trial of treatments for acute SARS-CoV-2 infection in community settings.
Authors: Hosseini B; Upstream Lab, MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, Ontario, Canada.; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.; Division of Clinical Public Health, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Condon A; Department of Family Medicine, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada., da Costa BR; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Daley P; Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.; Eastern Regional Health Authority, St. John's, Newfoundland and Labrador, Canada., Greiver M; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Family and Community Medicine, North York General Hospital, Toronto, Ontario, Canada., Jüni P; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Lee TC; Department of Medicine, Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada., McBrien K; Department of Family Medicine, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada.; Department Community Health Sciences, University of Calgary, Calgary, Alberta, Canada., McDonald EG; Division of Experimental Medicine, Department of Medicine, McGill University, Montréal, Quebec, Canada.; Division of General Internal Medicine, Department of Medicine, McGill University, Montréal, Quebec, Canada., Murthy S; Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Selby P; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.; Division of Clinical Public Health, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.; Addiction Programs, Centre for Addiction and Mental Health, Toronto, Ontario, Canada., Andrew M; Department of Medicine (Division of Geriatric Medicine), Dalhousie University, Halifax, Nova Scotia, Canada., Aubrey-Bassler K; Primary Healthcare Research Unit, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada., Barber D; Department of Family Medicine, Queen's University, Kingston, Ontario, Canada., Barrett B; Medicine Nephrology, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada., Butler CC; Nuffield Department of Primary Health Care Sciences, University of Oxford, Oxford, UK., Crampton N; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada., Dahrouge S; Elisabeth Bruyere Research Institute, University of Ottawa, Ottawa, Ontario, Canada., Damji A; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada., Fowler R; Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Garies S; Department of Family Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Hudon C; Université de Sherbrooke, Sherbrooke, Quebec, Canada., Hulme J; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada., Isenor J; College of Pharmacy, Dalhousie University, Halifax, Nova Scotia, Canada.; Canadian Center for Vaccinology, Dalhousie University, Halifax, Nova Scotia, Canada., Jenkins DJA; Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.; Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada., Lall R; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada., LeBlanc A; VITAM Research Center on Sustainable Health, Sherbrooke, Quebec, Canada., Leong C; College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada., Little P; Primary Care Research Centre, School of Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton, UK., Lofters A; Department of Family and Community Medicine, Women's College Hospital, Toronto, Ontario, Canada.; Department of Family and Community Medicine, Women's College Hospital, Toronto, Ontario, Canada.; Department of Family and Community Medicine, St. Michael's Hospital, Toronto, Ontario, Canada.; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada., Logsetty S; Departments of Surgery and Psychiatry, University of Manitoba, Winnipeg, Manitoba, Canada., Lother S; Department of Internal Medicine, University of Manitoba Max Rady College of Medicine, Winnipeg, Manitoba, Canada.; Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada., Lussier MT; CHUM Research Center, Université de Montréal's affiliated hospital research center, Montréal, Québec, Canada.; Département de médecine de famille et de médecine d'urgence, Université de Montréal, Montréal, Québec, Canada., Maclaren L; Department of Family Medicine, McGill University Faculty of Medicine and Health Sciences, Montreal, Quebec, Canada., Mangin D; Public Health and General Practice, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand., Marshall EG; Family Medicine, Dalhousie University, Halifax, Nova Scotia, Canada., Marshall JC; Department of Surgery, University of Toronto, Toronto, Ontario, Canada., McCracken R; Family Medicine, Providence Health Care, Vancouver, British Columbia, Canada.; Family Practice, University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada., Moineddin R; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Orava B; Lawrence S Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada., Paquette JS; VITAM - Research Centre on Sustainable Health, Sherbrooke, Québec, Canada.; Département de médecine de famille et de médecine d'urgence, Université Laval, Quebec City, Québec, Canada.; Laboratoire ARIMED, Saint-Charles-Borromée, Québec, Canada., Park JJH; Department of Health Research Methods, Evidence and Impact (HEI), Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada., Persaud N; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Family and Community Medicine, St. Michael's Hospital, Toronto, Ontario, Canada.; MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada., Rac VE; Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.; Program for Health System and Technology Evaluation, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada., Ramsden VR; Department of Family Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Rayner J; Alliance for Healthier Communities, Toronto, Ontario, Canada., Sanchez-Ramirez DC; College of Rehabilitation Sciences, Department of Respiratory Therapy, University of Manitoba, Winnipeg, Manitoba, Canada., Saxinger L; Department of Medicine, Division of Infectious Diseases, University of Alberta Faculty of Medicine and Dentistry, Edmonton, Alberta, Canada., Shi H; Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, British Columbia, Canada., Singer A; Department of Family Medicine, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.; Manitoba Primary Care Research Network, Winnipeg, Manitoba, Canada., Spiwak R; Department of Surgery, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.; Manitoba Centre for Health Policy, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada., Srivastava A; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada., Sud A; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.; Research Institute, Humber River Health, Toronto, Ontario, Canada., Tarride JE; Department of Health Research Methods, Evidence and Impact (HEI), Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada., Telner D; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.; South East Toronto Family Health Team, Toronto, Ontario, Canada., Upshur REG; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.; Division of Clinical Public Health, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.; Joint Centre for Bioethics, University of Toronto, Toronto, Ontario, Canada., Walji S; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada., Walsh R; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.; Evaluative Clinical Sciences Platform, Integrated Community Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.; Sunnybrook Academic Family Health Team, Toronto, Ontario, Canada., Wilchesky M; Departments of Medicine and of Family Medicine, McGill University, Montreal, Quebec, Canada.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada., Wong ST; Centre for Health Services and Policy Research, University of British Columbia, Vancouver, British Columbia, Canada., Wood B; Thunder Bay Regional Health Research Institute, Thunder Bay, Ontario, Canada.; Dr. Gilles Arcand Centre for Health Equity, Northern Ontario School of Medicine, Thunder Bay, Ontario, Canada., Zarychanski R; Sections of Critical Care and Hematology/Medical Oncology, University of Manitoba, Winnipeg, Manitoba, Canada., Zelek B; Dr. Gilles Arcand Centre for Health Equity, Northern Ontario School of Medicine, Thunder Bay, Ontario, Canada., Keynan Y; Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada.; Department of Internal Medicine, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada., Piszczek J; Faculty of Pharmacy, The University of British Columbia, Vancouver, British Columbia, Canada., Warshafsky D; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.; Ontario Ministry of Health, Toronto, Ontario, Canada., Pinto AD; Upstream Lab, MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, Ontario, Canada andrew.pinto@utoronto.ca.; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.; Division of Clinical Public Health, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.; Department of Family and Community Medicine, St. Michael's Hospital, Toronto, Ontario, Canada.
Source: BMJ open [BMJ Open] 2025 Aug 03; Vol. 15 (8), pp. e097134. Date of Electronic Publication: 2025 Aug 03.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Canadian Adaptive Platform Trial of Treatments for COVID in Community Settings (CanTreatCOVID): protocol for a randomised controlled adaptive platform trial of treatments for acute SARS-CoV-2 infection in community settings.
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  Data: <searchLink fieldCode="AU" term="%22Hosseini+B%22">Hosseini B</searchLink>; Upstream Lab, MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, Ontario, Canada.; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.; Division of Clinical Public Health, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Condon+A%22">Condon A</searchLink>; Department of Family Medicine, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22da+Costa+BR%22">da Costa BR</searchLink>; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Daley+P%22">Daley P</searchLink>; Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.; Eastern Regional Health Authority, St. John's, Newfoundland and Labrador, Canada.<br /><searchLink fieldCode="AU" term="%22Greiver+M%22">Greiver M</searchLink>; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Family and Community Medicine, North York General Hospital, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Jüni+P%22">Jüni P</searchLink>; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Lee+TC%22">Lee TC</searchLink>; Department of Medicine, Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22McBrien+K%22">McBrien K</searchLink>; Department of Family Medicine, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada.; Department Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22McDonald+EG%22">McDonald EG</searchLink>; Division of Experimental Medicine, Department of Medicine, McGill University, Montréal, Quebec, Canada.; Division of General Internal Medicine, Department of Medicine, McGill University, Montréal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Murthy+S%22">Murthy S</searchLink>; Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Selby+P%22">Selby P</searchLink>; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.; Division of Clinical Public Health, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.; Addiction Programs, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Andrew+M%22">Andrew M</searchLink>; Department of Medicine (Division of Geriatric Medicine), Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Aubrey-Bassler+K%22">Aubrey-Bassler K</searchLink>; Primary Healthcare Research Unit, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.<br /><searchLink fieldCode="AU" term="%22Barber+D%22">Barber D</searchLink>; Department of Family Medicine, Queen's University, Kingston, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Barrett+B%22">Barrett B</searchLink>; Medicine Nephrology, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.<br /><searchLink fieldCode="AU" term="%22Butler+CC%22">Butler CC</searchLink>; Nuffield Department of Primary Health Care Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Crampton+N%22">Crampton N</searchLink>; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Dahrouge+S%22">Dahrouge S</searchLink>; Elisabeth Bruyere Research Institute, University of Ottawa, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Damji+A%22">Damji A</searchLink>; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Fowler+R%22">Fowler R</searchLink>; Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Garies+S%22">Garies S</searchLink>; Department of Family Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Hudon+C%22">Hudon C</searchLink>; Université de Sherbrooke, Sherbrooke, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Hulme+J%22">Hulme J</searchLink>; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Isenor+J%22">Isenor J</searchLink>; College of Pharmacy, Dalhousie University, Halifax, Nova Scotia, Canada.; Canadian Center for Vaccinology, Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Jenkins+DJA%22">Jenkins DJA</searchLink>; Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.; Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Lall+R%22">Lall R</searchLink>; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22LeBlanc+A%22">LeBlanc A</searchLink>; VITAM Research Center on Sustainable Health, Sherbrooke, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Leong+C%22">Leong C</searchLink>; College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Little+P%22">Little P</searchLink>; Primary Care Research Centre, School of Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Lofters+A%22">Lofters A</searchLink>; Department of Family and Community Medicine, Women's College Hospital, Toronto, Ontario, Canada.; Department of Family and Community Medicine, Women's College Hospital, Toronto, Ontario, Canada.; Department of Family and Community Medicine, St. Michael's Hospital, Toronto, Ontario, Canada.; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Logsetty+S%22">Logsetty S</searchLink>; Departments of Surgery and Psychiatry, University of Manitoba, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Lother+S%22">Lother S</searchLink>; Department of Internal Medicine, University of Manitoba Max Rady College of Medicine, Winnipeg, Manitoba, Canada.; Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Lussier+MT%22">Lussier MT</searchLink>; CHUM Research Center, Université de Montréal's affiliated hospital research center, Montréal, Québec, Canada.; Département de médecine de famille et de médecine d'urgence, Université de Montréal, Montréal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Maclaren+L%22">Maclaren L</searchLink>; Department of Family Medicine, McGill University Faculty of Medicine and Health Sciences, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Mangin+D%22">Mangin D</searchLink>; Public Health and General Practice, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand.<br /><searchLink fieldCode="AU" term="%22Marshall+EG%22">Marshall EG</searchLink>; Family Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Marshall+JC%22">Marshall JC</searchLink>; Department of Surgery, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22McCracken+R%22">McCracken R</searchLink>; Family Medicine, Providence Health Care, Vancouver, British Columbia, Canada.; Family Practice, University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Moineddin+R%22">Moineddin R</searchLink>; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Orava+B%22">Orava B</searchLink>; Lawrence S Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Paquette+JS%22">Paquette JS</searchLink>; VITAM - Research Centre on Sustainable Health, Sherbrooke, Québec, Canada.; Département de médecine de famille et de médecine d'urgence, Université Laval, Quebec City, Québec, Canada.; Laboratoire ARIMED, Saint-Charles-Borromée, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Park+JJH%22">Park JJH</searchLink>; Department of Health Research Methods, Evidence and Impact (HEI), Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Persaud+N%22">Persaud N</searchLink>; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Family and Community Medicine, St. Michael's Hospital, Toronto, Ontario, Canada.; MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Rac+VE%22">Rac VE</searchLink>; Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.; Program for Health System and Technology Evaluation, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ramsden+VR%22">Ramsden VR</searchLink>; Department of Family Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.<br /><searchLink fieldCode="AU" term="%22Rayner+J%22">Rayner J</searchLink>; Alliance for Healthier Communities, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Sanchez-Ramirez+DC%22">Sanchez-Ramirez DC</searchLink>; College of Rehabilitation Sciences, Department of Respiratory Therapy, University of Manitoba, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Saxinger+L%22">Saxinger L</searchLink>; Department of Medicine, Division of Infectious Diseases, University of Alberta Faculty of Medicine and Dentistry, Edmonton, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Shi+H%22">Shi H</searchLink>; Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Singer+A%22">Singer A</searchLink>; Department of Family Medicine, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.; Manitoba Primary Care Research Network, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Spiwak+R%22">Spiwak R</searchLink>; Department of Surgery, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.; Manitoba Centre for Health Policy, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Srivastava+A%22">Srivastava A</searchLink>; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Sud+A%22">Sud A</searchLink>; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.; Research Institute, Humber River Health, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Tarride+JE%22">Tarride JE</searchLink>; Department of Health Research Methods, Evidence and Impact (HEI), Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Telner+D%22">Telner D</searchLink>; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.; South East Toronto Family Health Team, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Upshur+REG%22">Upshur REG</searchLink>; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.; Division of Clinical Public Health, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.; Joint Centre for Bioethics, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Walji+S%22">Walji S</searchLink>; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Walsh+R%22">Walsh R</searchLink>; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.; Evaluative Clinical Sciences Platform, Integrated Community Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.; Sunnybrook Academic Family Health Team, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Wilchesky+M%22">Wilchesky M</searchLink>; Departments of Medicine and of Family Medicine, McGill University, Montreal, Quebec, Canada.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Wong+ST%22">Wong ST</searchLink>; Centre for Health Services and Policy Research, University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Wood+B%22">Wood B</searchLink>; Thunder Bay Regional Health Research Institute, Thunder Bay, Ontario, Canada.; Dr. Gilles Arcand Centre for Health Equity, Northern Ontario School of Medicine, Thunder Bay, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Zarychanski+R%22">Zarychanski R</searchLink>; Sections of Critical Care and Hematology/Medical Oncology, University of Manitoba, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Zelek+B%22">Zelek B</searchLink>; Dr. Gilles Arcand Centre for Health Equity, Northern Ontario School of Medicine, Thunder Bay, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Keynan+Y%22">Keynan Y</searchLink>; Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada.; Department of Internal Medicine, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Piszczek+J%22">Piszczek J</searchLink>; Faculty of Pharmacy, The University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Warshafsky+D%22">Warshafsky D</searchLink>; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.; Ontario Ministry of Health, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Pinto+AD%22">Pinto AD</searchLink>; Upstream Lab, MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, Ontario, Canada andrew.pinto@utoronto.ca.; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.; Division of Clinical Public Health, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.; Department of Family and Community Medicine, St. Michael's Hospital, Toronto, Ontario, Canada.
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  Data: <searchLink fieldCode="JN" term="%22101552874%22">BMJ open</searchLink> [BMJ Open] 2025 Aug 03; Vol. 15 (8), pp. e097134. <i>Date of Electronic Publication: </i>2025 Aug 03.
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      – TitleFull: Canadian Adaptive Platform Trial of Treatments for COVID in Community Settings (CanTreatCOVID): protocol for a randomised controlled adaptive platform trial of treatments for acute SARS-CoV-2 infection in community settings.
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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            NameFull: Jenkins DJA
      – PersonEntity:
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            NameFull: Lall R
      – PersonEntity:
          Name:
            NameFull: LeBlanc A
      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
          Name:
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      – PersonEntity:
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            NameFull: Moineddin R
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      – PersonEntity:
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          Name:
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      – PersonEntity:
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            NameFull: Saxinger L
      – PersonEntity:
          Name:
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      – PersonEntity:
          Name:
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      – PersonEntity:
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      – PersonEntity:
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            NameFull: Srivastava A
      – PersonEntity:
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      – PersonEntity:
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            NameFull: Tarride JE
      – PersonEntity:
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            NameFull: Telner D
      – PersonEntity:
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            NameFull: Upshur REG
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            NameFull: Walji S
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          Name:
            NameFull: Wilchesky M
      – PersonEntity:
          Name:
            NameFull: Wong ST
      – PersonEntity:
          Name:
            NameFull: Wood B
      – PersonEntity:
          Name:
            NameFull: Zarychanski R
      – PersonEntity:
          Name:
            NameFull: Zelek B
      – PersonEntity:
          Name:
            NameFull: Keynan Y
      – PersonEntity:
          Name:
            NameFull: Piszczek J
      – PersonEntity:
          Name:
            NameFull: Warshafsky D
      – PersonEntity:
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    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 03
              M: 08
              Text: 2025 Aug 03
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2044-6055
          Numbering:
            – Type: volume
              Value: 15
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: BMJ open
              Type: main
ResultId 1