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Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study.

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Title: Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study.
Authors: Skelton M; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK., Mundy J; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK., Ter Kuile AR; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK., Adey BN; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK., Armour C; Research Centre for Stress, Trauma & Related Conditions (STARC), School of Psychology, Queen's University Belfast, Belfast, Northern Ireland, UK., Buckman JEJ; Centre for Outcomes Research and Effectiveness (CORE), Research Department of Clinical, Educational and Health Psychology, University College London, London, UK.; iCope - Camden and Islington Psychological Therapies Services, Camden and Islington NHS Foundation Trust, London, UK., Coleman JRI; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK., Davies MR; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK., Hirsch CR; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; Chief Academic Officer for South London and Maudsley NHS Foundation Trust, London, UK., Hotopf M; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.; Chief Academic Officer for South London and Maudsley NHS Foundation Trust, London, UK., Jones IR; National Centre for Mental Health, Division of Psychiatry and Clinical Neuroscience, Cardiff University, Cardiff, UK., Kalsi G; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK., Krebs G; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; Chief Academic Officer for South London and Maudsley NHS Foundation Trust, London, UK., Lee SH; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK., Lin Y; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK., McIntosh AM; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Peel AJ; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK., Rayner C; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK., Rimes KA; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; Chief Academic Officer for South London and Maudsley NHS Foundation Trust, London, UK., Smith DJ; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Thompson KN; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK., Veale D; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.; Chief Academic Officer for South London and Maudsley NHS Foundation Trust, London, UK., Walters JTR; National Centre for Mental Health, Division of Psychiatry and Clinical Neuroscience, Cardiff University, Cardiff, UK., Hübel C; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; National Centre for Register-based Research, Aarhus Business and Social Sciences, Aarhus University, Aarhus, Denmark., Breen G; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK., Eley TC; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.
Source: Psychological medicine [Psychol Med] 2025 Aug 05; Vol. 55, pp. e224. Date of Electronic Publication: 2025 Aug 05.
Publication Type: Journal Article
Journal Info: Publisher: Cambridge University Press Country of Publication: England NLM ID: 1254142 Publication Model: Electronic Cited Medium: Internet ISSN: 1469-8978 (Electronic) Linking ISSN: 00332917 NLM ISO Abbreviation: Psychol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study.
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  Data: <searchLink fieldCode="AU" term="%22Skelton+M%22">Skelton M</searchLink>; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Mundy+J%22">Mundy J</searchLink>; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Ter+Kuile+AR%22">Ter Kuile AR</searchLink>; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Adey+BN%22">Adey BN</searchLink>; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Armour+C%22">Armour C</searchLink>; Research Centre for Stress, Trauma & Related Conditions (STARC), School of Psychology, Queen's University Belfast, Belfast, Northern Ireland, UK.<br /><searchLink fieldCode="AU" term="%22Buckman+JEJ%22">Buckman JEJ</searchLink>; Centre for Outcomes Research and Effectiveness (CORE), Research Department of Clinical, Educational and Health Psychology, University College London, London, UK.; iCope - Camden and Islington Psychological Therapies Services, Camden and Islington NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Coleman+JRI%22">Coleman JRI</searchLink>; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Davies+MR%22">Davies MR</searchLink>; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Hirsch+CR%22">Hirsch CR</searchLink>; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; Chief Academic Officer for South London and Maudsley NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Hotopf+M%22">Hotopf M</searchLink>; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.; Chief Academic Officer for South London and Maudsley NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Jones+IR%22">Jones IR</searchLink>; National Centre for Mental Health, Division of Psychiatry and Clinical Neuroscience, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Kalsi+G%22">Kalsi G</searchLink>; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Krebs+G%22">Krebs G</searchLink>; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; Chief Academic Officer for South London and Maudsley NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Lee+SH%22">Lee SH</searchLink>; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Lin+Y%22">Lin Y</searchLink>; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22McIntosh+AM%22">McIntosh AM</searchLink>; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Peel+AJ%22">Peel AJ</searchLink>; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Rayner+C%22">Rayner C</searchLink>; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Rimes+KA%22">Rimes KA</searchLink>; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; Chief Academic Officer for South London and Maudsley NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Smith+DJ%22">Smith DJ</searchLink>; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Thompson+KN%22">Thompson KN</searchLink>; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Veale+D%22">Veale D</searchLink>; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.; Chief Academic Officer for South London and Maudsley NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Walters+JTR%22">Walters JTR</searchLink>; National Centre for Mental Health, Division of Psychiatry and Clinical Neuroscience, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Hübel+C%22">Hübel C</searchLink>; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; National Centre for Register-based Research, Aarhus Business and Social Sciences, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Breen+G%22">Breen G</searchLink>; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Eley+TC%22">Eley TC</searchLink>; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.
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