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Lactate signalling leads to aggregation of immune-inflammatory hotspots and SLC5A12 blockade promotes their resolution.

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Title: Lactate signalling leads to aggregation of immune-inflammatory hotspots and SLC5A12 blockade promotes their resolution.
Authors: Certo M; Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK. m.certo@bham.ac.uk., Pontarini E; Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK., Gilbert SG; School of Mathematics, University of Birmingham, Birmingham, UK.; Birmingham Tissue Analytics, Institute of Translational Medicine, University of Birmingham, Birmingham, UK., Schmidt R; Sciomics GmbH, Neckargemünd, Germany., Turner JD; Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK., Lucchesi D; Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK., Apostolo D; Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK.; Department of Translational Medicine, University of Piemonte Orientale (UPO), Novara, Italy., Cavallaro G; Department of Physics and Astronomy, University of Catania, Catania, Italy., Smith CG; Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK., Colafrancesco S; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, and Rheumatology and Clinical Immunology, Istituto di Ricovero e Cura a Carattere Scientifico, IRCCS Humanitas Research Hospital, Rozzano, Italy., Campos J; Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Propath UK Limited, Hereford, UK., Nayar S; Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK., Schröder C; Sciomics GmbH, Neckargemünd, Germany., Fisher BA; Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.; NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK., Spill F; School of Mathematics, University of Birmingham, Birmingham, UK., Bombardieri M; Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK. m.bombardieri@qmul.ac.uk., Mauro C; Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK. c.mauro@bham.ac.uk.
Source: Nature metabolism [Nat Metab] 2025 Aug; Vol. 7 (8), pp. 1663-1680. Date of Electronic Publication: 2025 Aug 04.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Certo+M%22">Certo M</searchLink>; Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK. m.certo@bham.ac.uk.<br /><searchLink fieldCode="AU" term="%22Pontarini+E%22">Pontarini E</searchLink>; Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Gilbert+SG%22">Gilbert SG</searchLink>; School of Mathematics, University of Birmingham, Birmingham, UK.; Birmingham Tissue Analytics, Institute of Translational Medicine, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Schmidt+R%22">Schmidt R</searchLink>; Sciomics GmbH, Neckargemünd, Germany.<br /><searchLink fieldCode="AU" term="%22Turner+JD%22">Turner JD</searchLink>; Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Lucchesi+D%22">Lucchesi D</searchLink>; Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Apostolo+D%22">Apostolo D</searchLink>; Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK.; Department of Translational Medicine, University of Piemonte Orientale (UPO), Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Cavallaro+G%22">Cavallaro G</searchLink>; Department of Physics and Astronomy, University of Catania, Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Smith+CG%22">Smith CG</searchLink>; Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Colafrancesco+S%22">Colafrancesco S</searchLink>; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, and Rheumatology and Clinical Immunology, Istituto di Ricovero e Cura a Carattere Scientifico, IRCCS Humanitas Research Hospital, Rozzano, Italy.<br /><searchLink fieldCode="AU" term="%22Campos+J%22">Campos J</searchLink>; Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Propath UK Limited, Hereford, UK.<br /><searchLink fieldCode="AU" term="%22Nayar+S%22">Nayar S</searchLink>; Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Schröder+C%22">Schröder C</searchLink>; Sciomics GmbH, Neckargemünd, Germany.<br /><searchLink fieldCode="AU" term="%22Fisher+BA%22">Fisher BA</searchLink>; Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.; NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Spill+F%22">Spill F</searchLink>; School of Mathematics, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Bombardieri+M%22">Bombardieri M</searchLink>; Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK. m.bombardieri@qmul.ac.uk.<br /><searchLink fieldCode="AU" term="%22Mauro+C%22">Mauro C</searchLink>; Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK. c.mauro@bham.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101736592%22">Nature metabolism</searchLink> [Nat Metab] 2025 Aug; Vol. 7 (8), pp. 1663-1680. <i>Date of Electronic Publication: </i>2025 Aug 04.
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