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First evaluation in multiple sclerosis using PET tracer [18F]3F4AP demonstrates heterogeneous binding across lesions.

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Title: First evaluation in multiple sclerosis using PET tracer [18F]3F4AP demonstrates heterogeneous binding across lesions.
Authors: Tiss A; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA., Michaelson NM; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA., Russo AW; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA., Ramos-Torres KM; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA., Sun Y; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA., DaSilva NE; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA., Noel JM; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA., Liu F; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA., Gong K; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA., Huang SY; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA., Popko B; Feinberg School of Medicine, Department of Neurology, Northwestern University, Chicago, IL, 60611, USA., Baker S; Department of Cellular and Tissue Imaging, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., Klawiter EC; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. eklawiter@mgh.harvard.edu., Brugarolas P; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. pbrugarolas@mgh.harvard.edu.
Source: European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2026 Jan; Vol. 53 (2), pp. 1125-1138. Date of Electronic Publication: 2025 Aug 05.
Publication Type: Clinical Trial, Phase I; Journal Article
Journal Info: Publisher: Springer-Verlag Berlin Country of Publication: Germany NLM ID: 101140988 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1619-7089 (Electronic) Linking ISSN: 16197070 NLM ISO Abbreviation: Eur J Nucl Med Mol Imaging Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: First evaluation in multiple sclerosis using PET tracer [<superscript>18</superscript>F]3F4AP demonstrates heterogeneous binding across lesions.
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  Data: <searchLink fieldCode="AU" term="%22Tiss+A%22">Tiss A</searchLink>; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Michaelson+NM%22">Michaelson NM</searchLink>; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Russo+AW%22">Russo AW</searchLink>; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Ramos-Torres+KM%22">Ramos-Torres KM</searchLink>; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22DaSilva+NE%22">DaSilva NE</searchLink>; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Noel+JM%22">Noel JM</searchLink>; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Liu+F%22">Liu F</searchLink>; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Gong+K%22">Gong K</searchLink>; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Huang+SY%22">Huang SY</searchLink>; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Popko+B%22">Popko B</searchLink>; Feinberg School of Medicine, Department of Neurology, Northwestern University, Chicago, IL, 60611, USA.<br /><searchLink fieldCode="AU" term="%22Baker+S%22">Baker S</searchLink>; Department of Cellular and Tissue Imaging, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.<br /><searchLink fieldCode="AU" term="%22Klawiter+EC%22">Klawiter EC</searchLink>; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. eklawiter@mgh.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Brugarolas+P%22">Brugarolas P</searchLink>; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. pbrugarolas@mgh.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%22101140988%22">European journal of nuclear medicine and molecular imaging</searchLink> [Eur J Nucl Med Mol Imaging] 2026 Jan; Vol. 53 (2), pp. 1125-1138. <i>Date of Electronic Publication: </i>2025 Aug 05.
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              Text: 2026 Jan
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