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The psychoplastogen tabernanthalog induces neuroplasticity without proximate immediate early gene activation.

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Title: The psychoplastogen tabernanthalog induces neuroplasticity without proximate immediate early gene activation.
Authors: Aarrestad IK; Neuroscience Graduate Program, University of California, Davis, Davis, CA, USA.; Institute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, CA, USA., Cameron LP; Neuroscience Graduate Program, University of California, Davis, Davis, CA, USA., Fenton EM; Neuroscience Graduate Program, University of California, Davis, Davis, CA, USA.; Institute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, CA, USA., Casey AB; Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA., Rijsketic DR; Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Tensor Analytics, LLC, Salt Lake City, UT, USA., Patel SD; Department of Chemistry, University of California, Davis, Davis, CA, USA., Sambyal R; Department of Chemistry, University of California, Davis, Davis, CA, USA., Johnson SB; Department of Psychiatry and Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA., Ly C; Department of Chemistry, University of California, Davis, Davis, CA, USA., Viswanathan J; Department of Chemistry, University of California, Davis, Davis, CA, USA., Barragan EV; Neuroscience Graduate Program, University of California, Davis, Davis, CA, USA., Lozano SA; Neuroscience Graduate Program, University of California, Davis, Davis, CA, USA.; Institute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, CA, USA., Seban N; Neuroscience Graduate Program, University of California, Davis, Davis, CA, USA.; Institute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, CA, USA., Hu H; Integrative Genetics and Genomics Graduate Program, University of California, Davis, Davis, CA, USA., Powell NA; Delix Therapeutics, Inc., Bedford, MA, USA., Chytil M; Delix Therapeutics, Inc., Bedford, MA, USA., Meyer R; Delix Therapeutics, Inc., Bedford, MA, USA., Rose D; Expressive Neuroscience, LLC, Syracuse, NY, USA., Hempel C; Expressive Neuroscience, LLC, Syracuse, NY, USA., Olson E; Expressive Neuroscience, LLC, Syracuse, NY, USA.; Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA., Hansen HD; Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Madsen CA; Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Knudsen GM; Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Redd C; Translucence Biosystems, Inc., Irvine, CA, USA., Wheeler DG; Translucence Biosystems, Inc., Irvine, CA, USA., Guanzon N; Translucence Biosystems, Inc., Irvine, CA, USA., Muir J; Center for Neuroscience, University of California, Davis, Davis, CA, USA.; Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA, USA., Hennessey JJ; Department of Cell Biology, Neurobiology and Anatomy, Neuroscience Research Center and Cancer Center, Medical College of Wisconsin, Milwaukee, WI, USA., Quon G; Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA, USA., McCorvy JD; Department of Cell Biology, Neurobiology and Anatomy, Neuroscience Research Center and Cancer Center, Medical College of Wisconsin, Milwaukee, WI, USA., Gandhi SP; Translucence Biosystems, Inc., Irvine, CA, USA.; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA., Rasmussen K; Delix Therapeutics, Inc., Bedford, MA, USA., Liston C; Department of Psychiatry and Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA., Gray JA; Institute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, CA, USA.; Center for Neuroscience, University of California, Davis, Davis, CA, USA.; Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA, USA.; Department of Psychiatry and Behavioral Sciences, School of Medicine, University of California, Davis, Sacramento, CA, USA., Heifets BD; Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA., Nord AS; Institute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, CA, USA.; Center for Neuroscience, University of California, Davis, Davis, CA, USA.; Department of Psychiatry and Behavioral Sciences, School of Medicine, University of California, Davis, Sacramento, CA, USA.; Department of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA, USA., Kim CK; Institute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, CA, USA.; Center for Neuroscience, University of California, Davis, Davis, CA, USA.; Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA, USA., Olson DE; Institute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, CA, USA. deolson@ucdavis.edu.; Department of Chemistry, University of California, Davis, Davis, CA, USA. deolson@ucdavis.edu.; Center for Neuroscience, University of California, Davis, Davis, CA, USA. deolson@ucdavis.edu.; Department of Biochemistry & Molecular Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA. deolson@ucdavis.edu.
Source: Nature neuroscience [Nat Neurosci] 2025 Sep; Vol. 28 (9), pp. 1919-1931. Date of Electronic Publication: 2025 Aug 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE
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