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Modification of belantamab mafodotin dosing to balance efficacy and tolerability in the DREAMM-7 and DREAMM-8 trials.

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Title: Modification of belantamab mafodotin dosing to balance efficacy and tolerability in the DREAMM-7 and DREAMM-8 trials.
Authors: Mateos MV; Hospital Universitario de Salamanca/Instituto de Investigación Biomédica de Salamanca/Cancer Research Center/Ciberonc, Salamanca, Spain., Trudel S; Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, ON, Canada., Quach H; St Vincent's Hospital Melbourne, University of Melbourne, Melbourne, VIC, Australia., Robak P; Medical University of Łódź, Łódź, Poland., Beksac M; Department of Hematology, Liv Hospital Ankara, İstinye University, Ankara, Turkey., Pour L; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic., Hus M; Medical University of Lublin, Lublin, Poland., Kim K; Sungkyunkwan University, Samsung Medical Center, Seoul, Republic of Korea., Zherebtsova V; Gorodskaya Klinicheskaya Bol'nitsa Im. S.p. Botkina, Moscow, Russia., Delimpasi S; General Hospital Evangelismos, Athens, Greece., Jelínek T; Department of Hematooncology, University Hospital Ostrava and Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic., Ward C; The Royal North Shore Hospital, Sydney, NSW, Australia., Ho PJ; Royal Prince Alfred Hospital and University of Sydney, Camperdown, NSW, Australia., Vorobyev V; Leningrad Regional Clinical Hospital, Saint Petersburg, Russia., Pitombeira de Lacerda M; Universidade da Região de Joinville and Centro de Hematologia e Oncologia, Joinville, Brazil., Aparecida-Martinez G; Hospital das Clínicas and Instituto do Câncer do Estado de São Paulo, Universidade de São Paulo, São Paulo, Brazil., Spicka I; First Faculty of Medicine, Charles University and General Hospital, Prague, Czech Republic., Radocha J; 4th Department of Internal Medicine - Hematology, University Hospital Hradec Králové, Faculty of Medicine in Hradec Králové, Charles University, Hradec Králové, Czech Republic., Cavo M; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Cerchione C; Hematology Unit, Istituto Romagnolo per lo Studio dei Tumori 'Dino Amadori,' Istituto di Ricovero e Cura a Carattere Scientifico, Meldola, Italy., Fu C; The First Affiliated Hospital of Soochow University, Jiangsu, China., Suzuki K; Division of Clinical Oncology/Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan., Rogers R; GSK, Collegeville, PA., Phillips-Jones A; GSK, Stevenage, United Kingdom., Wang Z; GSK, Collegeville, PA., Baig H; GSK, Mississauga, ON, Canada., Wilkes J; GSK, Stevenage, United Kingdom., Zhou XL; GSK, Waltham, MA., Lewis E; GSK, Research Triangle Park, NC., Eccersley L; GSK, London, United Kingdom., Sule N; GSK, Collegeville, PA., Paka P; GSK, Collegeville, PA., Opalinska JB; GSK, Collegeville, PA., Mukhopadhyay P; GSK, Collegeville, PA., Hungria V; Clínica São Germano, São Paulo, Brazil., Dimopoulos MA; Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.; Department of Medicine, Korea University, Seoul, Republic of Korea.
Source: Blood advances [Blood Adv] 2025 Nov 25; Vol. 9 (22), pp. 5708-5719.
Publication Type: Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial
Journal Info: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 101698425 Publication Model: Print Cited Medium: Internet ISSN: 2473-9537 (Electronic) Linking ISSN: 24739529 NLM ISO Abbreviation: Blood Adv Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Modification of belantamab mafodotin dosing to balance efficacy and tolerability in the DREAMM-7 and DREAMM-8 trials.
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  Data: <searchLink fieldCode="AU" term="%22Mateos+MV%22">Mateos MV</searchLink>; Hospital Universitario de Salamanca/Instituto de Investigación Biomédica de Salamanca/Cancer Research Center/Ciberonc, Salamanca, Spain.<br /><searchLink fieldCode="AU" term="%22Trudel+S%22">Trudel S</searchLink>; Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Quach+H%22">Quach H</searchLink>; St Vincent's Hospital Melbourne, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Robak+P%22">Robak P</searchLink>; Medical University of Łódź, Łódź, Poland.<br /><searchLink fieldCode="AU" term="%22Beksac+M%22">Beksac M</searchLink>; Department of Hematology, Liv Hospital Ankara, İstinye University, Ankara, Turkey.<br /><searchLink fieldCode="AU" term="%22Pour+L%22">Pour L</searchLink>; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Hus+M%22">Hus M</searchLink>; Medical University of Lublin, Lublin, Poland.<br /><searchLink fieldCode="AU" term="%22Kim+K%22">Kim K</searchLink>; Sungkyunkwan University, Samsung Medical Center, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Zherebtsova+V%22">Zherebtsova V</searchLink>; Gorodskaya Klinicheskaya Bol'nitsa Im. S.p. Botkina, Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Delimpasi+S%22">Delimpasi S</searchLink>; General Hospital Evangelismos, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Jelínek+T%22">Jelínek T</searchLink>; Department of Hematooncology, University Hospital Ostrava and Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Ward+C%22">Ward C</searchLink>; The Royal North Shore Hospital, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Ho+PJ%22">Ho PJ</searchLink>; Royal Prince Alfred Hospital and University of Sydney, Camperdown, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Vorobyev+V%22">Vorobyev V</searchLink>; Leningrad Regional Clinical Hospital, Saint Petersburg, Russia.<br /><searchLink fieldCode="AU" term="%22Pitombeira+de+Lacerda+M%22">Pitombeira de Lacerda M</searchLink>; Universidade da Região de Joinville and Centro de Hematologia e Oncologia, Joinville, Brazil.<br /><searchLink fieldCode="AU" term="%22Aparecida-Martinez+G%22">Aparecida-Martinez G</searchLink>; Hospital das Clínicas and Instituto do Câncer do Estado de São Paulo, Universidade de São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Spicka+I%22">Spicka I</searchLink>; First Faculty of Medicine, Charles University and General Hospital, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Radocha+J%22">Radocha J</searchLink>; 4th Department of Internal Medicine - Hematology, University Hospital Hradec Králové, Faculty of Medicine in Hradec Králové, Charles University, Hradec Králové, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Cavo+M%22">Cavo M</searchLink>; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Cerchione+C%22">Cerchione C</searchLink>; Hematology Unit, Istituto Romagnolo per lo Studio dei Tumori 'Dino Amadori,' Istituto di Ricovero e Cura a Carattere Scientifico, Meldola, Italy.<br /><searchLink fieldCode="AU" term="%22Fu+C%22">Fu C</searchLink>; The First Affiliated Hospital of Soochow University, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Suzuki+K%22">Suzuki K</searchLink>; Division of Clinical Oncology/Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Rogers+R%22">Rogers R</searchLink>; GSK, Collegeville, PA.<br /><searchLink fieldCode="AU" term="%22Phillips-Jones+A%22">Phillips-Jones A</searchLink>; GSK, Stevenage, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; GSK, Collegeville, PA.<br /><searchLink fieldCode="AU" term="%22Baig+H%22">Baig H</searchLink>; GSK, Mississauga, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Wilkes+J%22">Wilkes J</searchLink>; GSK, Stevenage, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Zhou+XL%22">Zhou XL</searchLink>; GSK, Waltham, MA.<br /><searchLink fieldCode="AU" term="%22Lewis+E%22">Lewis E</searchLink>; GSK, Research Triangle Park, NC.<br /><searchLink fieldCode="AU" term="%22Eccersley+L%22">Eccersley L</searchLink>; GSK, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Sule+N%22">Sule N</searchLink>; GSK, Collegeville, PA.<br /><searchLink fieldCode="AU" term="%22Paka+P%22">Paka P</searchLink>; GSK, Collegeville, PA.<br /><searchLink fieldCode="AU" term="%22Opalinska+JB%22">Opalinska JB</searchLink>; GSK, Collegeville, PA.<br /><searchLink fieldCode="AU" term="%22Mukhopadhyay+P%22">Mukhopadhyay P</searchLink>; GSK, Collegeville, PA.<br /><searchLink fieldCode="AU" term="%22Hungria+V%22">Hungria V</searchLink>; Clínica São Germano, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Dimopoulos+MA%22">Dimopoulos MA</searchLink>; Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.; Department of Medicine, Korea University, Seoul, Republic of Korea.
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  Data: <searchLink fieldCode="JN" term="%22101698425%22">Blood advances</searchLink> [Blood Adv] 2025 Nov 25; Vol. 9 (22), pp. 5708-5719.
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  Data: Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial
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