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Pathway polygenic risk scores (pPRS) for the analysis of gene-environment interaction.

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Title: Pathway polygenic risk scores (pPRS) for the analysis of gene-environment interaction.
Authors: Gauderman WJ; Division of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America., Fu Y; Division of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America., Queme B; Division of Bioinformatics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America., Kawaguchi E; Division of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America., Wang Y; Division of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America., Morrison J; Division of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Chan A; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America., Gruber SB; Center for Precision Medicine and Department of Medical Oncology, City of Hope National Medical Center, Duarte, California, United States of America., Keku T; University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America., Li L; Department of Family Medicine, UVA Comprehensive Cancer Center, UVA School of Medicine, Charlottesville, Virginia, United States of America., Moreno V; Oncology Data Analytics Program, Catalan Institute of Oncology (ICO), L'Hospitalet de Llobregat, Barcelona, Spain.; Colorectal Cancer Group, ONCOBELL Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.; Department of Clinical Sciences, Faculty of Medicine and Health Sciences and Universitat de Barcelona Institute of Complex Systems (UBICS), University of Barcelona (UB), L'Hospitalet de Llobregat, Barcelona, Spain.; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain., Pellatt AJ; Intermountain Health, Salt Lake City, Utah, United States of America., Peters U; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America.; Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, United States of America., Samadder NJ; Mayo Clinic Comprehensive Cancer Center, Phoenix, Arizona, United States of America., Schmit SL; Genomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.; Population and Cancer Prevention Program, Case Comprehensive Cancer Center, Cleveland, Ohio, United States of America., Ulrich CM; Huntsman Cancer Institute, Salt Lake City, Utah, United States of America.; Department of Population Sciences, University of Utah, Salt Lake City, Utah, United States of America., Um C; Department of Population Science, American Cancer Society, Atlanta, GeorgiaUnited States of America., Wu A; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America., Lewinger JP; Division of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America., Drew DA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America., Mi H; Division of Bioinformatics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America.
Source: PLoS genetics [PLoS Genet] 2025 Aug 05; Vol. 21 (8), pp. e1011543. Date of Electronic Publication: 2025 Aug 05 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7404 (Electronic) Linking ISSN: 15537390 NLM ISO Abbreviation: PLoS Genet Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Gauderman+WJ%22">Gauderman WJ</searchLink>; Division of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Fu+Y%22">Fu Y</searchLink>; Division of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Queme+B%22">Queme B</searchLink>; Division of Bioinformatics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Kawaguchi+E%22">Kawaguchi E</searchLink>; Division of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Division of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Morrison+J%22">Morrison J</searchLink>; Division of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Brenner+H%22">Brenner H</searchLink>; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Chan+A%22">Chan A</searchLink>; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Gruber+SB%22">Gruber SB</searchLink>; Center for Precision Medicine and Department of Medical Oncology, City of Hope National Medical Center, Duarte, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Keku+T%22">Keku T</searchLink>; University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Department of Family Medicine, UVA Comprehensive Cancer Center, UVA School of Medicine, Charlottesville, Virginia, United States of America.<br /><searchLink fieldCode="AU" term="%22Moreno+V%22">Moreno V</searchLink>; Oncology Data Analytics Program, Catalan Institute of Oncology (ICO), L'Hospitalet de Llobregat, Barcelona, Spain.; Colorectal Cancer Group, ONCOBELL Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.; Department of Clinical Sciences, Faculty of Medicine and Health Sciences and Universitat de Barcelona Institute of Complex Systems (UBICS), University of Barcelona (UB), L'Hospitalet de Llobregat, Barcelona, Spain.; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Pellatt+AJ%22">Pellatt AJ</searchLink>; Intermountain Health, Salt Lake City, Utah, United States of America.<br /><searchLink fieldCode="AU" term="%22Peters+U%22">Peters U</searchLink>; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America.; Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Samadder+NJ%22">Samadder NJ</searchLink>; Mayo Clinic Comprehensive Cancer Center, Phoenix, Arizona, United States of America.<br /><searchLink fieldCode="AU" term="%22Schmit+SL%22">Schmit SL</searchLink>; Genomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.; Population and Cancer Prevention Program, Case Comprehensive Cancer Center, Cleveland, Ohio, United States of America.<br /><searchLink fieldCode="AU" term="%22Ulrich+CM%22">Ulrich CM</searchLink>; Huntsman Cancer Institute, Salt Lake City, Utah, United States of America.; Department of Population Sciences, University of Utah, Salt Lake City, Utah, United States of America.<br /><searchLink fieldCode="AU" term="%22Um+C%22">Um C</searchLink>; Department of Population Science, American Cancer Society, Atlanta, GeorgiaUnited States of America.<br /><searchLink fieldCode="AU" term="%22Wu+A%22">Wu A</searchLink>; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Lewinger+JP%22">Lewinger JP</searchLink>; Division of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Drew+DA%22">Drew DA</searchLink>; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Mi+H%22">Mi H</searchLink>; Division of Bioinformatics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America.
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