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Metabolome Profiling of Yokukansan in Preventing Postoperative Delirium in Elderly Cancer Patients: A Reverse Translational Study.

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Title: Metabolome Profiling of Yokukansan in Preventing Postoperative Delirium in Elderly Cancer Patients: A Reverse Translational Study.
Authors: Sadahiro R; Department of Psycho-Oncology, National Cancer Center Hospital, Tokyo, Japan.; Department of Immune Medicine, National Cancer Center Research Institute, Tokyo, Japan., Ohbuchi K; Department of Psycho-Oncology, National Cancer Center Hospital, Tokyo, Japan.; Tsumura Advanced Technology Research Laboratories, Tsumura & Co., Ibaraki, Japan., Nakaya T; Tsumura Advanced Technology Research Laboratories, Tsumura & Co., Ibaraki, Japan., Manabe S; Department of Anesthesiology and Resuscitology, Okayama University Hospital, Okayama, Japan., Wada S; Department of Psycho-Oncology, National Cancer Center Hospital, Tokyo, Japan.; Division of Quality Assurance Programs, Institute for Cancer Control, National Cancer Center, Tokyo, Japan., Yamaguchi T; Division of Biostatistics, Tohoku University Graduate School of Medicine, Tokyo, Japan., Sugimoto M; Institute for Advanced Biosciences, Keio University, Yamagata, Japan.; Institute of Medical Sciences, Tokyo Medical University, Tokyo, Japan., Shimizu K; Department of Psycho-Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan., Sato T; Department of Anesthesiology and Intensive Care Medicine, National Cancer Center Hospital, Tokyo, Japan., Esaki M; Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Tokyo, Japan., Daiko H; Department of Esophageal Surgery, National Cancer Center Hospital, Tokyo, Japan., Yoshimoto S; Department of Head and Neck Surgery, National Cancer Center Hospital, Tokyo, Japan., Kanemitsu Y; Department of Colorectal Surgery, National Cancer Center Hospital, Tokyo, Japan., Kawai A; Department of Musculoskeletal Oncology and Rehabilitation, National Cancer Center Hospital, Tokyo, Japan., Ishikawa M; Department of Gynecology, National Cancer Center Hospital, Tokyo, Japan., Matsui Y; Department of Urology, National Cancer Center Hospital, Tokyo, Japan., Aoki K; Department of Immune Medicine, National Cancer Center Research Institute, Tokyo, Japan., Ueno T; Department of Dentistry, National Cancer Center Hospital, Tokyo, Japan., Matsuoka H; Department of Psycho-Oncology, National Cancer Center Hospital, Tokyo, Japan., Uezono Y; Department of Pain Control Research, The Jikei University School of Medicine, Tokyo, Japan.
Source: Psychiatry and clinical neurosciences [Psychiatry Clin Neurosci] 2025 Oct; Vol. 79 (10), pp. 685-696. Date of Electronic Publication: 2025 Aug 05.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Blackwell Science Country of Publication: Australia NLM ID: 9513551 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1440-1819 (Electronic) Linking ISSN: 13231316 NLM ISO Abbreviation: Psychiatry Clin Neurosci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Metabolome Profiling of Yokukansan in Preventing Postoperative Delirium in Elderly Cancer Patients: A Reverse Translational Study.
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  Data: <searchLink fieldCode="AU" term="%22Sadahiro+R%22">Sadahiro R</searchLink>; Department of Psycho-Oncology, National Cancer Center Hospital, Tokyo, Japan.; Department of Immune Medicine, National Cancer Center Research Institute, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ohbuchi+K%22">Ohbuchi K</searchLink>; Department of Psycho-Oncology, National Cancer Center Hospital, Tokyo, Japan.; Tsumura Advanced Technology Research Laboratories, Tsumura & Co., Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Nakaya+T%22">Nakaya T</searchLink>; Tsumura Advanced Technology Research Laboratories, Tsumura & Co., Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Manabe+S%22">Manabe S</searchLink>; Department of Anesthesiology and Resuscitology, Okayama University Hospital, Okayama, Japan.<br /><searchLink fieldCode="AU" term="%22Wada+S%22">Wada S</searchLink>; Department of Psycho-Oncology, National Cancer Center Hospital, Tokyo, Japan.; Division of Quality Assurance Programs, Institute for Cancer Control, National Cancer Center, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yamaguchi+T%22">Yamaguchi T</searchLink>; Division of Biostatistics, Tohoku University Graduate School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sugimoto+M%22">Sugimoto M</searchLink>; Institute for Advanced Biosciences, Keio University, Yamagata, Japan.; Institute of Medical Sciences, Tokyo Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Shimizu+K%22">Shimizu K</searchLink>; Department of Psycho-Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sato+T%22">Sato T</searchLink>; Department of Anesthesiology and Intensive Care Medicine, National Cancer Center Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Esaki+M%22">Esaki M</searchLink>; Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Daiko+H%22">Daiko H</searchLink>; Department of Esophageal Surgery, National Cancer Center Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yoshimoto+S%22">Yoshimoto S</searchLink>; Department of Head and Neck Surgery, National Cancer Center Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kanemitsu+Y%22">Kanemitsu Y</searchLink>; Department of Colorectal Surgery, National Cancer Center Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kawai+A%22">Kawai A</searchLink>; Department of Musculoskeletal Oncology and Rehabilitation, National Cancer Center Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ishikawa+M%22">Ishikawa M</searchLink>; Department of Gynecology, National Cancer Center Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Matsui+Y%22">Matsui Y</searchLink>; Department of Urology, National Cancer Center Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Aoki+K%22">Aoki K</searchLink>; Department of Immune Medicine, National Cancer Center Research Institute, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ueno+T%22">Ueno T</searchLink>; Department of Dentistry, National Cancer Center Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Matsuoka+H%22">Matsuoka H</searchLink>; Department of Psycho-Oncology, National Cancer Center Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Uezono+Y%22">Uezono Y</searchLink>; Department of Pain Control Research, The Jikei University School of Medicine, Tokyo, Japan.
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  Data: <searchLink fieldCode="JN" term="%229513551%22">Psychiatry and clinical neurosciences</searchLink> [Psychiatry Clin Neurosci] 2025 Oct; Vol. 79 (10), pp. 685-696. <i>Date of Electronic Publication: </i>2025 Aug 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Blackwell+Science%22">Blackwell Science </searchLink><i>Country of Publication: </i>Australia <i>NLM ID: </i>9513551 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1440-1819 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213231316%22">13231316 </searchLink><i>NLM ISO Abbreviation: </i>Psychiatry Clin Neurosci <i>Subsets: </i>MEDLINE
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