Chromatin Perturbation Promotes Susceptibility to Hypomethylating Agents.

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Title: Chromatin Perturbation Promotes Susceptibility to Hypomethylating Agents.
Authors: Schneider C; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Alexe G; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Merickel LA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA., Meyer A; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA., Swift ML; Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Serafim RB; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA., Basanthakumar AT; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA., Taillon A; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA., Salhotra S; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA., Boniolo F; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lambo S; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rodriguez Y; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Häupl B; Goethe University Frankfurt, University Hospital, Frankfurt am Main, Germany.; Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany.; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Frankfurt am Main, Germany., George RE; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA., Root DE; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Oellerich T; Goethe University Frankfurt, University Hospital, Frankfurt am Main, Germany.; Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany.; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Frankfurt am Main, Germany., Hovestadt V; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chowdhury D; Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Stegmaier K; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Jul 31. Date of Electronic Publication: 2025 Jul 31.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Schneider+C%22">Schneider C</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Alexe+G%22">Alexe G</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Merickel+LA%22">Merickel LA</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Meyer+A%22">Meyer A</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Swift+ML%22">Swift ML</searchLink>; Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Serafim+RB%22">Serafim RB</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Basanthakumar+AT%22">Basanthakumar AT</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Taillon+A%22">Taillon A</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Salhotra+S%22">Salhotra S</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Boniolo+F%22">Boniolo F</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lambo+S%22">Lambo S</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez+Y%22">Rodriguez Y</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Häupl+B%22">Häupl B</searchLink>; Goethe University Frankfurt, University Hospital, Frankfurt am Main, Germany.; Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany.; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22George+RE%22">George RE</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Root+DE%22">Root DE</searchLink>; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Oellerich+T%22">Oellerich T</searchLink>; Goethe University Frankfurt, University Hospital, Frankfurt am Main, Germany.; Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany.; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Hovestadt+V%22">Hovestadt V</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chowdhury+D%22">Chowdhury D</searchLink>; Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Stegmaier+K%22">Stegmaier K</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
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