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Discovery of chromatin-based determinants of azacytidine and decitabine anti-cancer activity.

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Title: Discovery of chromatin-based determinants of azacytidine and decitabine anti-cancer activity.
Authors: Puram RV; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Yin Q; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Liu Y; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Rutter JC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Bondeson D; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Systems Biology, UMass Chan Medical School, Worcester, MA, USA., Saberi MC; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Miller L; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Du M; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Nguyen K; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Batzli DL; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Woldemichael HB; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Täger C; Institute for Experimental Internal Medicine, Otto-von-Guericke-Universität, Magdeburg, Germany., Goldstein A; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Chu MY; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Guo Q; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Mani DR; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Naumann M; Institute for Experimental Internal Medicine, Otto-von-Guericke-Universität, Magdeburg, Germany., Ronan MM; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Rees MG; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Ip BC; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Kocak M; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Slabicki M; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Krantz Family Center for Cancer Research, Mass General Cancer Center, Boston, MA, USA., Doench JG; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Roth JA; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Carr SA; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Udeshi ND; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Wu J; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Golub TR; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Aug 01. Date of Electronic Publication: 2025 Aug 01.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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DbLabel: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Discovery of chromatin-based determinants of azacytidine and decitabine anti-cancer activity.
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  Data: <searchLink fieldCode="AU" term="%22Puram+RV%22">Puram RV</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yin+Q%22">Yin Q</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rutter+JC%22">Rutter JC</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bondeson+D%22">Bondeson D</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Systems Biology, UMass Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Saberi+MC%22">Saberi MC</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Miller+L%22">Miller L</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Du+M%22">Du M</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+K%22">Nguyen K</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Batzli+DL%22">Batzli DL</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Woldemichael+HB%22">Woldemichael HB</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Täger+C%22">Täger C</searchLink>; Institute for Experimental Internal Medicine, Otto-von-Guericke-Universität, Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Goldstein+A%22">Goldstein A</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chu+MY%22">Chu MY</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Guo+Q%22">Guo Q</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mani+DR%22">Mani DR</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Naumann+M%22">Naumann M</searchLink>; Institute for Experimental Internal Medicine, Otto-von-Guericke-Universität, Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Ronan+MM%22">Ronan MM</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rees+MG%22">Rees MG</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ip+BC%22">Ip BC</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kocak+M%22">Kocak M</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Slabicki+M%22">Slabicki M</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Krantz Family Center for Cancer Research, Mass General Cancer Center, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Doench+JG%22">Doench JG</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Roth+JA%22">Roth JA</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Carr+SA%22">Carr SA</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Udeshi+ND%22">Udeshi ND</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Golub+TR%22">Golub TR</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
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              Text: 2025 Aug 01
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