PART and amyloid cascade hypotheses are alive and well (but are not so simple). Scientific commentary on: "Sequence and trajectory of early Alzheimer's disease-related tau inclusions in the hippocampal formation of cases without amyloid-beta deposits".

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Title: PART and amyloid cascade hypotheses are alive and well (but are not so simple). Scientific commentary on: "Sequence and trajectory of early Alzheimer's disease-related tau inclusions in the hippocampal formation of cases without amyloid-beta deposits".
Authors: Nelson PT; University of Kentucky, Rm 111B, Sanders-Brown Center on Aging, 800 S. Limestone Ave., Lexington, KY, 40536, USA. peter.nelson@uky.edu., Crary JF; Mount Sinai Icahn School of Medicine, New York, NY, USA.
Source: Acta neuropathologica [Acta Neuropathol] 2025 Aug 06; Vol. 150 (1), pp. 14. Date of Electronic Publication: 2025 Aug 06.
Publication Type: Letter; Comment
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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ISSN:1432-0533
DOI:10.1007/s00401-025-02920-4