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Regulatory KIR+CD8+ T cells are elevated during human pregnancy.

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Title: Regulatory KIR+CD8+ T cells are elevated during human pregnancy.
Authors: Li J; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA., Wang X; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA., Lackner AI; Department of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA., Narasimhan P; Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA 94305, USA., Li L; Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94158, USA.; Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94158, USA., Mallajosyula V; Institute of Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA., Johnson MM; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA., Höbler AL; Department of Obstetrics and Gynecology, Reproductive Biology Unit, Maternal-Fetal Immunology Group, Medical University of Vienna, 1090 Vienna, Austria., Kirosingh AS; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA., Braun AE; Department of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA.; Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA 94305, USA., Nankya F; Infectious Diseases Research Collaboration, Kampala, Uganda., Musinguzi K; Infectious Diseases Research Collaboration, Kampala, Uganda., Kakuru A; Infectious Diseases Research Collaboration, Kampala, Uganda., Kamya M; Infectious Diseases Research Collaboration, Kampala, Uganda.; Department of Medicine, Makerere University, Kampala, Uganda., Rosenthal PJ; Department of Medicine, University of California San Francisco, San Francisco, CA 94158, USA., Dorsey G; Department of Medicine, University of California San Francisco, San Francisco, CA 94158, USA., Jagannathan P; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Medicine, Stanford University, Stanford, CA 94305, USA., Angelo M; Department of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA., Pollheimer J; Department of Obstetrics and Gynecology, Reproductive Biology Unit, Maternal-Fetal Immunology Group, Medical University of Vienna, 1090 Vienna, Austria., Gaw SL; Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94158, USA.; Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94158, USA., Winn VD; Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA 94305, USA., Nadeau KC; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA., Davis MM; Institute of Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Source: Science translational medicine [Sci Transl Med] 2025 Aug 06; Vol. 17 (810), pp. eadm7697. Date of Electronic Publication: 2025 Aug 06.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: Regulatory KIR<superscript>+</superscript>CD8<superscript>+</superscript> T cells are elevated during human pregnancy.
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  Data: <searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA.<br /><searchLink fieldCode="AU" term="%22Lackner+AI%22">Lackner AI</searchLink>; Department of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Narasimhan+P%22">Narasimhan P</searchLink>; Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94158, USA.; Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Mallajosyula+V%22">Mallajosyula V</searchLink>; Institute of Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+MM%22">Johnson MM</searchLink>; Department of Environmental Health, Harvard T. 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Chan School of Public Health, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Höbler+AL%22">Höbler AL</searchLink>; Department of Obstetrics and Gynecology, Reproductive Biology Unit, Maternal-Fetal Immunology Group, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Kirosingh+AS%22">Kirosingh AS</searchLink>; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Braun+AE%22">Braun AE</searchLink>; Department of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA.; Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Nankya+F%22">Nankya F</searchLink>; Infectious Diseases Research Collaboration, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Musinguzi+K%22">Musinguzi K</searchLink>; Infectious Diseases Research Collaboration, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Kakuru+A%22">Kakuru A</searchLink>; Infectious Diseases Research Collaboration, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Kamya+M%22">Kamya M</searchLink>; Infectious Diseases Research Collaboration, Kampala, Uganda.; Department of Medicine, Makerere University, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Rosenthal+PJ%22">Rosenthal PJ</searchLink>; Department of Medicine, University of California San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Dorsey+G%22">Dorsey G</searchLink>; Department of Medicine, University of California San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Jagannathan+P%22">Jagannathan P</searchLink>; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Medicine, Stanford University, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Angelo+M%22">Angelo M</searchLink>; Department of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Pollheimer+J%22">Pollheimer J</searchLink>; Department of Obstetrics and Gynecology, Reproductive Biology Unit, Maternal-Fetal Immunology Group, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Gaw+SL%22">Gaw SL</searchLink>; Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94158, USA.; Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Winn+VD%22">Winn VD</searchLink>; Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Nadeau+KC%22">Nadeau KC</searchLink>; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Davis+MM%22">Davis MM</searchLink>; Institute of Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
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