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Design, Synthesis and Biological Evaluation of Chromeno[3,4-b]xanthones as Multifunctional Agents for Alzheimer's Disease.

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Title: Design, Synthesis and Biological Evaluation of Chromeno[3,4-b]xanthones as Multifunctional Agents for Alzheimer's Disease.
Authors: Malafaia D; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal., Brás NF; LAQV-REQUIMTE, Department of Chemistry and Biochemistry, University of Porto, 4169-007 Porto, Portugal., Sampietro A; Laboratory of Medicinal Chemistry (CSIC Associated Unit), Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona, 08007 Barcelona, Spain., Quintelas I; LAQV-REQUIMTE, Department of Chemistry and Biochemistry, University of Porto, 4169-007 Porto, Portugal., Ferreira P; LAQV-REQUIMTE, Department of Chemistry and Biochemistry, University of Porto, 4169-007 Porto, Portugal., Melo L; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal., Saavedra J; Molecular Neurobiology Group, Institute for Health Research and Innovation (i3S), Institute for Molecular and Cellular Biology (IBMC), 4150-180 Porto, Portugal.; Department of Molecular Biology, Abel Salazar Institute of Biomedical Sciences (ICBAS), University of Porto, 4099-002 Porto, Portugal., Martinez-Gonzalez L; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28040 Madrid, Spain.; Centro de Investigaciones Biologicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain., Pereira M; Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal., Sarabando J; Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal., König L; Ruprecht-Karls Universität Institut für Pharmazie und Molekulare BiotechnologieIm Neuenheimer Feld 329, D-69120 Heidelberg, Germany., Cardoso I; Molecular Neurobiology Group, Institute for Health Research and Innovation (i3S), Institute for Molecular and Cellular Biology (IBMC), 4150-180 Porto, Portugal.; Department of Molecular Biology, Abel Salazar Institute of Biomedical Sciences (ICBAS), University of Porto, 4099-002 Porto, Portugal., Ribeiro D; Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal., Soares AR; Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal., Sabaté R; Department of Pharmacy and Pharmaceutical Technology, Department of Physical Chemistry, School of Pharmacy, iUniversity of Barcelona, 08028 Barcelona, Spain.; Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028 Barcelona, Spain., Fricker G; Ruprecht-Karls Universität Institut für Pharmazie und Molekulare BiotechnologieIm Neuenheimer Feld 329, D-69120 Heidelberg, Germany., Martinez A; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28040 Madrid, Spain.; Centro de Investigaciones Biologicas 'Margarita Salas' (CIB-CSIC), Ramiro de Maeztu 9, Madrid 28040, Spain., Fernandes PA; LAQV-REQUIMTE, Department of Chemistry and Biochemistry, University of Porto, 4169-007 Porto, Portugal., Silva AMS; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal., Albuquerque HMT; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Source: ACS chemical neuroscience [ACS Chem Neurosci] 2025 Aug 20; Vol. 16 (16), pp. 3184-3203. Date of Electronic Publication: 2025 Aug 06.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE
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  Data: Design, Synthesis and Biological Evaluation of Chromeno[3,4-b]xanthones as Multifunctional Agents for Alzheimer's Disease.
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  Data: <searchLink fieldCode="AU" term="%22Malafaia+D%22">Malafaia D</searchLink>; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.<br /><searchLink fieldCode="AU" term="%22Brás+NF%22">Brás NF</searchLink>; LAQV-REQUIMTE, Department of Chemistry and Biochemistry, University of Porto, 4169-007 Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Sampietro+A%22">Sampietro A</searchLink>; Laboratory of Medicinal Chemistry (CSIC Associated Unit), Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona, 08007 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Quintelas+I%22">Quintelas I</searchLink>; LAQV-REQUIMTE, Department of Chemistry and Biochemistry, University of Porto, 4169-007 Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Ferreira+P%22">Ferreira P</searchLink>; LAQV-REQUIMTE, Department of Chemistry and Biochemistry, University of Porto, 4169-007 Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Melo+L%22">Melo L</searchLink>; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.<br /><searchLink fieldCode="AU" term="%22Saavedra+J%22">Saavedra J</searchLink>; Molecular Neurobiology Group, Institute for Health Research and Innovation (i3S), Institute for Molecular and Cellular Biology (IBMC), 4150-180 Porto, Portugal.; Department of Molecular Biology, Abel Salazar Institute of Biomedical Sciences (ICBAS), University of Porto, 4099-002 Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Martinez-Gonzalez+L%22">Martinez-Gonzalez L</searchLink>; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28040 Madrid, Spain.; Centro de Investigaciones Biologicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Pereira+M%22">Pereira M</searchLink>; Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal.<br /><searchLink fieldCode="AU" term="%22Sarabando+J%22">Sarabando J</searchLink>; Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal.<br /><searchLink fieldCode="AU" term="%22König+L%22">König L</searchLink>; Ruprecht-Karls Universität Institut für Pharmazie und Molekulare BiotechnologieIm Neuenheimer Feld 329, D-69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Cardoso+I%22">Cardoso I</searchLink>; Molecular Neurobiology Group, Institute for Health Research and Innovation (i3S), Institute for Molecular and Cellular Biology (IBMC), 4150-180 Porto, Portugal.; Department of Molecular Biology, Abel Salazar Institute of Biomedical Sciences (ICBAS), University of Porto, 4099-002 Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Ribeiro+D%22">Ribeiro D</searchLink>; Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal.<br /><searchLink fieldCode="AU" term="%22Soares+AR%22">Soares AR</searchLink>; Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal.<br /><searchLink fieldCode="AU" term="%22Sabaté+R%22">Sabaté R</searchLink>; Department of Pharmacy and Pharmaceutical Technology, Department of Physical Chemistry, School of Pharmacy, iUniversity of Barcelona, 08028 Barcelona, Spain.; Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Fricker+G%22">Fricker G</searchLink>; Ruprecht-Karls Universität Institut für Pharmazie und Molekulare BiotechnologieIm Neuenheimer Feld 329, D-69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Martinez+A%22">Martinez A</searchLink>; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28040 Madrid, Spain.; Centro de Investigaciones Biologicas 'Margarita Salas' (CIB-CSIC), Ramiro de Maeztu 9, Madrid 28040, Spain.<br /><searchLink fieldCode="AU" term="%22Fernandes+PA%22">Fernandes PA</searchLink>; LAQV-REQUIMTE, Department of Chemistry and Biochemistry, University of Porto, 4169-007 Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Silva+AMS%22">Silva AMS</searchLink>; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.<br /><searchLink fieldCode="AU" term="%22Albuquerque+HMT%22">Albuquerque HMT</searchLink>; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
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  Data: <searchLink fieldCode="JN" term="%22101525337%22">ACS chemical neuroscience</searchLink> [ACS Chem Neurosci] 2025 Aug 20; Vol. 16 (16), pp. 3184-3203. <i>Date of Electronic Publication: </i>2025 Aug 06.
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