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Pseudomonas infections persisting after CFTR modulators are widespread throughout the lungs and drive lung inflammation.

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Title: Pseudomonas infections persisting after CFTR modulators are widespread throughout the lungs and drive lung inflammation.
Authors: Durfey SL; Department of Microbiology, University of Washington, Seattle, WA 98195, USA., Kapnadak SG; Department of Medicine, University of Washington, Seattle, WA 98195, USA., Pena T; Department of Medicine, University of Iowa, Iowa City, IA 52242, USA., Willmering MM; Department of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45221, USA., Godwin JD; Department of Radiology, University of Washington, Seattle, WA 98195, USA., Teresi ME; Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA., Heltshe SL; Department of Pediatrics, University of Washington, Seattle, WA 98195, USA; Cystic Fibrosis Foundation Therapeutics Development Network Coordinating Center, Seattle Children's Research Institute, Seattle, WA 98145, USA., Vo AT; Department of Microbiology, University of Washington, Seattle, WA 98195, USA., Villacreses RA; Department of Medicine, University of Iowa, Iowa City, IA 52242, USA., Aliukonyte I; Department of Radiology and Nuclear Medicine, Erasmus MC, 3015 CN, Rotterdam, the Netherlands; Department of Paediatric Pulmonology and Allergology, Erasmus MC-Sophia Children's Hospital, 3015 CN, Rotterdam, the Netherlands., Boyken L; Department of Pathology, University of Iowa, Iowa City, IA 52242, USA., Stroik MR; Department of Medicine, University of Iowa, Iowa City, IA 52242, USA., Morgan SJ; Department of Microbiology, University of Washington, Seattle, WA 98195, USA., Wang GM; Department of Microbiology, University of Washington, Seattle, WA 98195, USA., Betts HL; Department of Microbiology, University of Washington, Seattle, WA 98195, USA., Zhang S; Department of Microbiology, University of Washington, Seattle, WA 98195, USA., Goss CH; Department of Medicine, University of Washington, Seattle, WA 98195, USA; Department of Pediatrics, University of Washington, Seattle, WA 98195, USA; Cystic Fibrosis Foundation Therapeutics Development Network Coordinating Center, Seattle Children's Research Institute, Seattle, WA 98145, USA., Clancy JP; Cystic Fibrosis Foundation, Bethesda, MD 20814, USA., Aitken ML; Department of Medicine, University of Washington, Seattle, WA 98195, USA., Steele C; Department of Microbiology and Immunology, Tulane University, New Orleans, LA 70118, USA., Feder AF; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA 98102, USA., Esther CR Jr; Marsico Lung Institute, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Pediatrics, University of North Carolina, Chapel Hill, NC 27599, USA., Tiddens HAWM; Department of Radiology and Nuclear Medicine, Erasmus MC, 3015 CN, Rotterdam, the Netherlands; Department of Paediatric Pulmonology and Allergology, Erasmus MC-Sophia Children's Hospital, 3015 CN, Rotterdam, the Netherlands; Thirona, 6525 CN, Nijmegen, the Netherlands., Woods JC; Department of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45221, USA., Stoltz DA; Department of Medicine, University of Iowa, Iowa City, IA 52242, USA; Pappajohn Biomedical Institute, University of Iowa, Iowa City, IA 52242, USA., Singh PK; Department of Microbiology, University of Washington, Seattle, WA 98195, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA. Electronic address: singhpr@uw.edu.
Source: Cell host & microbe [Cell Host Microbe] 2025 Aug 13; Vol. 33 (8), pp. 1428-1445.e4. Date of Electronic Publication: 2025 Aug 05.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1934-6069 (Electronic) Linking ISSN: 19313128 NLM ISO Abbreviation: Cell Host Microbe Subsets: MEDLINE
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  Data: Pseudomonas infections persisting after CFTR modulators are widespread throughout the lungs and drive lung inflammation.
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  Data: <searchLink fieldCode="AU" term="%22Durfey+SL%22">Durfey SL</searchLink>; Department of Microbiology, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Kapnadak+SG%22">Kapnadak SG</searchLink>; Department of Medicine, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Pena+T%22">Pena T</searchLink>; Department of Medicine, University of Iowa, Iowa City, IA 52242, USA.<br /><searchLink fieldCode="AU" term="%22Willmering+MM%22">Willmering MM</searchLink>; Department of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45221, USA.<br /><searchLink fieldCode="AU" term="%22Godwin+JD%22">Godwin JD</searchLink>; Department of Radiology, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Teresi+ME%22">Teresi ME</searchLink>; Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA.<br /><searchLink fieldCode="AU" term="%22Heltshe+SL%22">Heltshe SL</searchLink>; Department of Pediatrics, University of Washington, Seattle, WA 98195, USA; Cystic Fibrosis Foundation Therapeutics Development Network Coordinating Center, Seattle Children's Research Institute, Seattle, WA 98145, USA.<br /><searchLink fieldCode="AU" term="%22Vo+AT%22">Vo AT</searchLink>; Department of Microbiology, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Villacreses+RA%22">Villacreses RA</searchLink>; Department of Medicine, University of Iowa, Iowa City, IA 52242, USA.<br /><searchLink fieldCode="AU" term="%22Aliukonyte+I%22">Aliukonyte I</searchLink>; Department of Radiology and Nuclear Medicine, Erasmus MC, 3015 CN, Rotterdam, the Netherlands; Department of Paediatric Pulmonology and Allergology, Erasmus MC-Sophia Children's Hospital, 3015 CN, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Boyken+L%22">Boyken L</searchLink>; Department of Pathology, University of Iowa, Iowa City, IA 52242, USA.<br /><searchLink fieldCode="AU" term="%22Stroik+MR%22">Stroik MR</searchLink>; Department of Medicine, University of Iowa, Iowa City, IA 52242, USA.<br /><searchLink fieldCode="AU" term="%22Morgan+SJ%22">Morgan SJ</searchLink>; Department of Microbiology, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Wang+GM%22">Wang GM</searchLink>; Department of Microbiology, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Betts+HL%22">Betts HL</searchLink>; Department of Microbiology, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; Department of Microbiology, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Goss+CH%22">Goss CH</searchLink>; Department of Medicine, University of Washington, Seattle, WA 98195, USA; Department of Pediatrics, University of Washington, Seattle, WA 98195, USA; Cystic Fibrosis Foundation Therapeutics Development Network Coordinating Center, Seattle Children's Research Institute, Seattle, WA 98145, USA.<br /><searchLink fieldCode="AU" term="%22Clancy+JP%22">Clancy JP</searchLink>; Cystic Fibrosis Foundation, Bethesda, MD 20814, USA.<br /><searchLink fieldCode="AU" term="%22Aitken+ML%22">Aitken ML</searchLink>; Department of Medicine, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Steele+C%22">Steele C</searchLink>; Department of Microbiology and Immunology, Tulane University, New Orleans, LA 70118, USA.<br /><searchLink fieldCode="AU" term="%22Feder+AF%22">Feder AF</searchLink>; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA 98102, USA.<br /><searchLink fieldCode="AU" term="%22Esther+CR+Jr%22">Esther CR Jr</searchLink>; Marsico Lung Institute, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Pediatrics, University of North Carolina, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Tiddens+HAWM%22">Tiddens HAWM</searchLink>; Department of Radiology and Nuclear Medicine, Erasmus MC, 3015 CN, Rotterdam, the Netherlands; Department of Paediatric Pulmonology and Allergology, Erasmus MC-Sophia Children's Hospital, 3015 CN, Rotterdam, the Netherlands; Thirona, 6525 CN, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Woods+JC%22">Woods JC</searchLink>; Department of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45221, USA.<br /><searchLink fieldCode="AU" term="%22Stoltz+DA%22">Stoltz DA</searchLink>; Department of Medicine, University of Iowa, Iowa City, IA 52242, USA; Pappajohn Biomedical Institute, University of Iowa, Iowa City, IA 52242, USA.<br /><searchLink fieldCode="AU" term="%22Singh+PK%22">Singh PK</searchLink>; Department of Microbiology, University of Washington, Seattle, WA 98195, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA. Electronic address: singhpr@uw.edu.
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  Data: <searchLink fieldCode="JN" term="%22101302316%22">Cell host & microbe</searchLink> [Cell Host Microbe] 2025 Aug 13; Vol. 33 (8), pp. 1428-1445.e4. <i>Date of Electronic Publication: </i>2025 Aug 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101302316 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1934-6069 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219313128%22">19313128 </searchLink><i>NLM ISO Abbreviation: </i>Cell Host Microbe <i>Subsets: </i>MEDLINE
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