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IRX3 controls a SUMOylation-dependent differentiation switch in adipocyte precursor cells.

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Title: IRX3 controls a SUMOylation-dependent differentiation switch in adipocyte precursor cells.
Authors: Bjune JI; Mohn Research Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.; Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.; Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway., Laber S; Medical Research Council Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, UK., Lawrence-Archer L; Mohn Research Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.; Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway., Nothnagel PMC; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, Blindern, Oslo, Norway., Yamada S; Center of Translational Oral Research-Tissue engineering, Department of Clinical Dentistry, University of Bergen, Bergen, Norway., Zhao X; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, Blindern, Oslo, Norway., Panahandeh Strømland P; Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway., Al-Sharabi N; Center of Translational Oral Research-Tissue engineering, Department of Clinical Dentistry, University of Bergen, Bergen, Norway., Mustafa K; Center of Translational Oral Research-Tissue engineering, Department of Clinical Dentistry, University of Bergen, Bergen, Norway., Njølstad PR; Mohn Research Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Pediatrics and Adolescents, Haukeland University Hospital, Bergen, Norway., Claussnitzer M; Mohn Research Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Cox RD; Medical Research Council Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, UK., Chymkowitch P; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, Blindern, Oslo, Norway. pierre.chymkowitch@ibv.uio.no., Mellgren G; Mohn Research Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway. gunnar.mellgren@uib.no.; Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway. gunnar.mellgren@uib.no.; Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway. gunnar.mellgren@uib.no., Dankel SN; Mohn Research Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway. simon.dankel@uib.no.; Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway. simon.dankel@uib.no.; Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway. simon.dankel@uib.no.
Source: Nature communications [Nat Commun] 2025 Aug 06; Vol. 16 (1), pp. 7248. Date of Electronic Publication: 2025 Aug 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: IRX3 controls a SUMOylation-dependent differentiation switch in adipocyte precursor cells.
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  Data: <searchLink fieldCode="AU" term="%22Bjune+JI%22">Bjune JI</searchLink>; Mohn Research Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.; Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.; Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Laber+S%22">Laber S</searchLink>; Medical Research Council Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, UK.<br /><searchLink fieldCode="AU" term="%22Lawrence-Archer+L%22">Lawrence-Archer L</searchLink>; Mohn Research Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.; Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Nothnagel+PMC%22">Nothnagel PMC</searchLink>; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, Blindern, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Yamada+S%22">Yamada S</searchLink>; Center of Translational Oral Research-Tissue engineering, Department of Clinical Dentistry, University of Bergen, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Zhao+X%22">Zhao X</searchLink>; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, Blindern, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Panahandeh+Strømland+P%22">Panahandeh Strømland P</searchLink>; Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Al-Sharabi+N%22">Al-Sharabi N</searchLink>; Center of Translational Oral Research-Tissue engineering, Department of Clinical Dentistry, University of Bergen, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Mustafa+K%22">Mustafa K</searchLink>; Center of Translational Oral Research-Tissue engineering, Department of Clinical Dentistry, University of Bergen, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Njølstad+PR%22">Njølstad PR</searchLink>; Mohn Research Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Pediatrics and Adolescents, Haukeland University Hospital, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Claussnitzer+M%22">Claussnitzer M</searchLink>; Mohn Research Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cox+RD%22">Cox RD</searchLink>; Medical Research Council Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, UK.<br /><searchLink fieldCode="AU" term="%22Chymkowitch+P%22">Chymkowitch P</searchLink>; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, Blindern, Oslo, Norway. pierre.chymkowitch@ibv.uio.no.<br /><searchLink fieldCode="AU" term="%22Mellgren+G%22">Mellgren G</searchLink>; Mohn Research Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway. gunnar.mellgren@uib.no.; Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway. gunnar.mellgren@uib.no.; Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway. gunnar.mellgren@uib.no.<br /><searchLink fieldCode="AU" term="%22Dankel+SN%22">Dankel SN</searchLink>; Mohn Research Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway. simon.dankel@uib.no.; Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway. simon.dankel@uib.no.; Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway. simon.dankel@uib.no.
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