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Depression Polygenicity and Disease Activity and Disability Worsening in Multiple Sclerosis.

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Title: Depression Polygenicity and Disease Activity and Disability Worsening in Multiple Sclerosis.
Authors: Manouchehrinia A; College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.; Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden., Fitzgerald KC; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD., Salter A; Department of Neurology, UT Southwestern, Dallas, TX., Marrie RA; Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.; Department of Medicine, Faculty of Medicine, Dalhousie University, Halifax, Canada.; Nova Scotia Health, Halifax, Canada., Alfredsson L; Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden.; Institute of Environmental Medicine, Karolinska Institutet, Solna, Sweden., Bernstein CN; Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada., Bolton JM; Department of Psychiatry, Max Rady College of Medicine Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada., Cutter G; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL., Fisk JD; Department of Medicine, Faculty of Medicine, Dalhousie University, Halifax, Canada.; Nova Scotia Health, Halifax, Canada.; Department of Psychiatry, Faculty of Medicine, Dalhousie University, Halifax, Canada., Graff LA; Department of Clinical Health Psychology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada., Hitchon CA; Department of Rheumatology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada., Hillert J; Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden., Kockum I; Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden., Lu Y; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden., Lublin FD; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY., McKay K; Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden., Olsson T; Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden., Patten S; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada., Patki A; Department of Psychiatry, Max Rady College of Medicine Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada., Riel H; College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada., Shchetynsky K; Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden., Stridh P; Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden., Tiwari HK; Department of Psychiatry, Max Rady College of Medicine Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada., Wolinsky JS; Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX., Kowalec K; College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden.; Department of Biochemistry and Medical Genetics, Max Rady College of Medicine Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
Source: Annals of neurology [Ann Neurol] 2025 Nov; Vol. 98 (5), pp. 1057-1069. Date of Electronic Publication: 2025 Aug 07.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7707449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8249 (Electronic) Linking ISSN: 03645134 NLM ISO Abbreviation: Ann Neurol Subsets: MEDLINE
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  Data: Depression Polygenicity and Disease Activity and Disability Worsening in Multiple Sclerosis.
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  Data: <searchLink fieldCode="AU" term="%22Manouchehrinia+A%22">Manouchehrinia A</searchLink>; College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.; Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Fitzgerald+KC%22">Fitzgerald KC</searchLink>; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Salter+A%22">Salter A</searchLink>; Department of Neurology, UT Southwestern, Dallas, TX.<br /><searchLink fieldCode="AU" term="%22Marrie+RA%22">Marrie RA</searchLink>; Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.; Department of Medicine, Faculty of Medicine, Dalhousie University, Halifax, Canada.; Nova Scotia Health, Halifax, Canada.<br /><searchLink fieldCode="AU" term="%22Alfredsson+L%22">Alfredsson L</searchLink>; Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden.; Institute of Environmental Medicine, Karolinska Institutet, Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Bernstein+CN%22">Bernstein CN</searchLink>; Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.<br /><searchLink fieldCode="AU" term="%22Bolton+JM%22">Bolton JM</searchLink>; Department of Psychiatry, Max Rady College of Medicine Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.<br /><searchLink fieldCode="AU" term="%22Cutter+G%22">Cutter G</searchLink>; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL.<br /><searchLink fieldCode="AU" term="%22Fisk+JD%22">Fisk JD</searchLink>; Department of Medicine, Faculty of Medicine, Dalhousie University, Halifax, Canada.; Nova Scotia Health, Halifax, Canada.; Department of Psychiatry, Faculty of Medicine, Dalhousie University, Halifax, Canada.<br /><searchLink fieldCode="AU" term="%22Graff+LA%22">Graff LA</searchLink>; Department of Clinical Health Psychology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.<br /><searchLink fieldCode="AU" term="%22Hitchon+CA%22">Hitchon CA</searchLink>; Department of Rheumatology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.<br /><searchLink fieldCode="AU" term="%22Hillert+J%22">Hillert J</searchLink>; Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Kockum+I%22">Kockum I</searchLink>; Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Lublin+FD%22">Lublin FD</searchLink>; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY.<br /><searchLink fieldCode="AU" term="%22McKay+K%22">McKay K</searchLink>; Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Olsson+T%22">Olsson T</searchLink>; Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Patten+S%22">Patten S</searchLink>; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada.<br /><searchLink fieldCode="AU" term="%22Patki+A%22">Patki A</searchLink>; Department of Psychiatry, Max Rady College of Medicine Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.<br /><searchLink fieldCode="AU" term="%22Riel+H%22">Riel H</searchLink>; College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.<br /><searchLink fieldCode="AU" term="%22Shchetynsky+K%22">Shchetynsky K</searchLink>; Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Stridh+P%22">Stridh P</searchLink>; Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Tiwari+HK%22">Tiwari HK</searchLink>; Department of Psychiatry, Max Rady College of Medicine Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.<br /><searchLink fieldCode="AU" term="%22Wolinsky+JS%22">Wolinsky JS</searchLink>; Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX.<br /><searchLink fieldCode="AU" term="%22Kowalec+K%22">Kowalec K</searchLink>; College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden.; Department of Biochemistry and Medical Genetics, Max Rady College of Medicine Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
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