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Paired single-cell and spatial transcriptional profiling reveals a central osteopontin macrophage response mediating tuberculous granuloma formation.

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Title: Paired single-cell and spatial transcriptional profiling reveals a central osteopontin macrophage response mediating tuberculous granuloma formation.
Authors: Pyle CJ; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, USA., Wang L; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA., Beerman RW; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA., Jain V; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, USA., Ohman HKE; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, USA., Thompson BA; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, USA., Abramson KR; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, USA., Ko DC; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA., Gregory SG; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, USA., Smith CM; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA., Neff JL; Department of Pathology, Duke University School of Medicine, Durham, North Carolina, USA., Richardson RJ; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom., Stout JE; Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA., Tobin DM; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, USA.
Source: MBio [mBio] 2025 Sep 10; Vol. 16 (9), pp. e0155925. Date of Electronic Publication: 2025 Aug 07.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Paired single-cell and spatial transcriptional profiling reveals a central osteopontin macrophage response mediating tuberculous granuloma formation.
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  Data: <searchLink fieldCode="AU" term="%22Pyle+CJ%22">Pyle CJ</searchLink>; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Beerman+RW%22">Beerman RW</searchLink>; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Jain+V%22">Jain V</searchLink>; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Ohman+HKE%22">Ohman HKE</searchLink>; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Thompson+BA%22">Thompson BA</searchLink>; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Abramson+KR%22">Abramson KR</searchLink>; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Ko+DC%22">Ko DC</searchLink>; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Gregory+SG%22">Gregory SG</searchLink>; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Smith+CM%22">Smith CM</searchLink>; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Neff+JL%22">Neff JL</searchLink>; Department of Pathology, Duke University School of Medicine, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Richardson+RJ%22">Richardson RJ</searchLink>; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Stout+JE%22">Stout JE</searchLink>; Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Tobin+DM%22">Tobin DM</searchLink>; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, USA.
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  Data: <searchLink fieldCode="JN" term="%22101519231%22">MBio</searchLink> [mBio] 2025 Sep 10; Vol. 16 (9), pp. e0155925. <i>Date of Electronic Publication: </i>2025 Aug 07.
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