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Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF: Evidence for Synergistic Benefit With GLP-1/Glucagon Agonism.

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Title: Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF: Evidence for Synergistic Benefit With GLP-1/Glucagon Agonism.
Authors: Doiron JE; Department of Pharmacology and Cardiovascular Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA., Elbatreek MH; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt., Xia H; Department of Pharmacology and Cardiovascular Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA., Yu X; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Gehred ND; Department of Anesthesiology, Medicine and Physiology, David Geffen School of Medicine at University of California, Los Angeles, California, USA., Gromova T; Department of Anesthesiology, Medicine and Physiology, David Geffen School of Medicine at University of California, Los Angeles, California, USA., Chen J; Gordian Biotechnology, South San Francisco, California, USA., Driver IH; Gordian Biotechnology, South San Francisco, California, USA., Muraoka N; Gordian Biotechnology, South San Francisco, California, USA., Jensen M; Gordian Biotechnology, South San Francisco, California, USA., Shambhu S; Gordian Biotechnology, South San Francisco, California, USA., Tang WHW; Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA; Center of Microbiome and Human Health, Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Cleveland, Ohio, USA., LaPenna KB; Department of Pharmacology and Cardiovascular Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA., Sharp TE 3rd; Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida, USA., Goodchild TT; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Xian M; Department of Chemistry, Brown University, Providence, Rhode Island, USA., Xu S; Department of Chemistry, Brown University, Providence, Rhode Island, USA., Quiriarte H; Vascular Metabolism Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA., Allerton TD; Vascular Metabolism Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA., Zagouras A; Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA., Wilcox J; Center of Microbiome and Human Health, Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Cleveland, Ohio, USA., Shah SJ; Northwestern University Medicine, Feinberg School of Medicine, Chicago, Illinois, USA., Pfeilschifter J; Institute of Pharmacology and Toxicology, Goethe University, Frankfurt am Main, Germany., Beck KF; Institute of Pharmacology and Toxicology, Goethe University, Frankfurt am Main, Germany., Vondriska TM; Department of Anesthesiology, Medicine and Physiology, David Geffen School of Medicine at University of California, Los Angeles, California, USA., Li Z; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Lefer DJ; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. Electronic address: David.Lefer@cshs.org.
Source: JACC. Basic to translational science [JACC Basic Transl Sci] 2025 Oct; Vol. 10 (10), pp. 101297. Date of Electronic Publication: 2025 Aug 06.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier on behalf of the American College of Cardiology Foundation Country of Publication: United States NLM ID: 101677259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2452-302X (Electronic) Linking ISSN: 2452302X NLM ISO Abbreviation: JACC Basic Transl Sci Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF: Evidence for Synergistic Benefit With GLP-1/Glucagon Agonism.
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  Data: <searchLink fieldCode="AU" term="%22Doiron+JE%22">Doiron JE</searchLink>; Department of Pharmacology and Cardiovascular Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.<br /><searchLink fieldCode="AU" term="%22Elbatreek+MH%22">Elbatreek MH</searchLink>; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.<br /><searchLink fieldCode="AU" term="%22Xia+H%22">Xia H</searchLink>; Department of Pharmacology and Cardiovascular Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.<br /><searchLink fieldCode="AU" term="%22Yu+X%22">Yu X</searchLink>; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Gehred+ND%22">Gehred ND</searchLink>; Department of Anesthesiology, Medicine and Physiology, David Geffen School of Medicine at University of California, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Gromova+T%22">Gromova T</searchLink>; Department of Anesthesiology, Medicine and Physiology, David Geffen School of Medicine at University of California, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Gordian Biotechnology, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Driver+IH%22">Driver IH</searchLink>; Gordian Biotechnology, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Muraoka+N%22">Muraoka N</searchLink>; Gordian Biotechnology, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Jensen+M%22">Jensen M</searchLink>; Gordian Biotechnology, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Shambhu+S%22">Shambhu S</searchLink>; Gordian Biotechnology, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Tang+WHW%22">Tang WHW</searchLink>; Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA; Center of Microbiome and Human Health, Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22LaPenna+KB%22">LaPenna KB</searchLink>; Department of Pharmacology and Cardiovascular Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.<br /><searchLink fieldCode="AU" term="%22Sharp+TE+3rd%22">Sharp TE 3rd</searchLink>; Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Goodchild+TT%22">Goodchild TT</searchLink>; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Xian+M%22">Xian M</searchLink>; Department of Chemistry, Brown University, Providence, Rhode Island, USA.<br /><searchLink fieldCode="AU" term="%22Xu+S%22">Xu S</searchLink>; Department of Chemistry, Brown University, Providence, Rhode Island, USA.<br /><searchLink fieldCode="AU" term="%22Quiriarte+H%22">Quiriarte H</searchLink>; Vascular Metabolism Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.<br /><searchLink fieldCode="AU" term="%22Allerton+TD%22">Allerton TD</searchLink>; Vascular Metabolism Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.<br /><searchLink fieldCode="AU" term="%22Zagouras+A%22">Zagouras A</searchLink>; Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Wilcox+J%22">Wilcox J</searchLink>; Center of Microbiome and Human Health, Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Shah+SJ%22">Shah SJ</searchLink>; Northwestern University Medicine, Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Pfeilschifter+J%22">Pfeilschifter J</searchLink>; Institute of Pharmacology and Toxicology, Goethe University, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Beck+KF%22">Beck KF</searchLink>; Institute of Pharmacology and Toxicology, Goethe University, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Vondriska+TM%22">Vondriska TM</searchLink>; Department of Anesthesiology, Medicine and Physiology, David Geffen School of Medicine at University of California, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Lefer+DJ%22">Lefer DJ</searchLink>; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. Electronic address: David.Lefer@cshs.org.
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  Data: <searchLink fieldCode="JN" term="%22101677259%22">JACC. Basic to translational science</searchLink> [JACC Basic Transl Sci] 2025 Oct; Vol. 10 (10), pp. 101297. <i>Date of Electronic Publication: </i>2025 Aug 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+on+behalf+of+the+American+College+of+Cardiology+Foundation%22">Elsevier on behalf of the American College of Cardiology Foundation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101677259 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2452-302X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222452302X%22">2452302X </searchLink><i>NLM ISO Abbreviation: </i>JACC Basic Transl Sci <i>Subsets: </i>PubMed not MEDLINE
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