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Bioassay-guided evaluation of a potent dual inhibitor of host and gut microbial α-glucosidases from Galla chinensis: mechanism insights and in silico studies.

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Title: Bioassay-guided evaluation of a potent dual inhibitor of host and gut microbial α-glucosidases from Galla chinensis: mechanism insights and in silico studies.
Authors: Sun HF; College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China., Yang T; College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China., Liu YT; College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China., Kang DN; College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China., Zhu GH; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Zhou Q; College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China., Yin YL; College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China., Hou XD; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Tang H; Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Pharmacy School of Shihezi University, Xinjiang 832003, China., Hou J; College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China. Electronic address: houjie@dmu.edu.cn.
Source: Fitoterapia [Fitoterapia] 2025 Sep; Vol. 185, pp. 106790. Date of Electronic Publication: 2025 Aug 05.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Sun+HF%22">Sun HF</searchLink>; College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.<br /><searchLink fieldCode="AU" term="%22Yang+T%22">Yang T</searchLink>; College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.<br /><searchLink fieldCode="AU" term="%22Liu+YT%22">Liu YT</searchLink>; College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.<br /><searchLink fieldCode="AU" term="%22Kang+DN%22">Kang DN</searchLink>; College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.<br /><searchLink fieldCode="AU" term="%22Zhu+GH%22">Zhu GH</searchLink>; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Q%22">Zhou Q</searchLink>; College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.<br /><searchLink fieldCode="AU" term="%22Yin+YL%22">Yin YL</searchLink>; College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.<br /><searchLink fieldCode="AU" term="%22Hou+XD%22">Hou XD</searchLink>; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Tang+H%22">Tang H</searchLink>; Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Pharmacy School of Shihezi University, Xinjiang 832003, China.<br /><searchLink fieldCode="AU" term="%22Hou+J%22">Hou J</searchLink>; College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China. Electronic address: houjie@dmu.edu.cn.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>16930290R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-6971 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220367326X%22">0367326X </searchLink><i>NLM ISO Abbreviation: </i>Fitoterapia <i>Subsets: </i>MEDLINE
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              Text: 2025 Sep
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