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Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistance.

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Title: Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistance.
Authors: Klope MT; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA., Talukder P; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA., Blank BR; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA., Chelebieva S; Dominican University of California, San Rafael, CA, USA., Chen J; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA., Fontaine SD; Departments of Chemistry and In Vivo Pharmacology, Tatara Therapeutics, San Francisco, CA, USA., Gonciarz RL; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA., Jaishankar P; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA., Lee GJ; Departments of Chemistry and In Vivo Pharmacology, Tatara Therapeutics, San Francisco, CA, USA., Legac J; Infectious Diseases Research Collaboration, Kampala, Uganda., Mathur V; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA., Narayan A; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA., Okitwi M; Infectious Diseases Research Collaboration, Kampala, Uganda., Orena S; Infectious Diseases Research Collaboration, Kampala, Uganda., Settineri NS; Advanced Light Source, Lawrence Berkeley National Laboratory and Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA., Tapia JA; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.; Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA, USA., Taremwa Y; Infectious Diseases Research Collaboration, Kampala, Uganda., Tumwebaze PK; Infectious Diseases Research Collaboration, Kampala, Uganda., Vinod A; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA., Burrows JN; Medicines for Malaria Venture, International Center Cointrin, Route de Pré-Bois 20, 1215 Geneva, Switzerland., Rosenthal PJ; Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA, USA., Cooper RA; Dominican University of California, San Rafael, CA, USA., Renslo AR; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Source: Science advances [Sci Adv] 2025 Aug 08; Vol. 11 (32), pp. eads9168. Date of Electronic Publication: 2025 Aug 08.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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