The clinical and economic impact of genotypic resistance testing for people diagnosed with persistent virological non-suppression on tenofovir-lamivudine-dolutegravir in South Africa: a modelling study.

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Title: The clinical and economic impact of genotypic resistance testing for people diagnosed with persistent virological non-suppression on tenofovir-lamivudine-dolutegravir in South Africa: a modelling study.
Authors: Hyle EP; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: ehyle@mgh.harvard.edu., Bekker LG; Desmond Tutu HIV Center, University of Cape Town, Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa., McCluskey SM; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; University of KwaZulu-Natal, Durban, South Africa., Chen W; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA., Sax PE; Harvard Medical School, Boston, MA, USA; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Moosa MY; Department of Infectious Diseases, University of KwaZulu-Natal, Durban, South Africa., Machoko M; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA., Bangs A; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA., Steegen K; National Priority Programme, National Health Laboratory Service, Johannesburg, South Africa; Department of Molecular Medicine and Haematology, University of the Witwatersrand, Johannesburg, South Africa., Siedner MJ; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; University of KwaZulu-Natal, Durban, South Africa; Africa Health Research Institute, KwaZulu-Natal, South Africa., van de Vijver DAMC; Department of Viroscience, Erasmus University Rotterdam, Rotterdam, Netherlands., Resch SC; Center for Health Decision Science, Harvard T H Chan School of Public Health, Boston, MA, USA., Neilan AM; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Division of General Academic Pediatrics, Massachusetts General Hospital, Boston, MA, USA., Phillips A; Epidemiology and Biostatistics, University College London, London, UK., Walensky RP; Harvard Kennedy School, Cambridge, MA, USA; American Academy of Berlin, Berlin, Germany., Lessells RJ; KwaZulu-Natal Research and Innovation Sequencing Platform, University of KwaZulu-Natal, Durban, South Africa., Weinstein MC; Center for Health Decision Science, Harvard T H Chan School of Public Health, Boston, MA, USA., Dugdale CM; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Wood R; Desmond Tutu HIV Center, University of Cape Town, Cape Town, South Africa., Freedberg KA; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA.
Source: The lancet. HIV [Lancet HIV] 2025 Sep; Vol. 12 (9), pp. e627-e637. Date of Electronic Publication: 2025 Aug 06.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101645355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3018 (Electronic) Linking ISSN: 23523018 NLM ISO Abbreviation: Lancet HIV Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2352-3018
DOI:10.1016/S2352-3018(25)00164-X