Medin drives Aβ40 to adopt Aβ42-like fibril polymorphs in vitro.

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Title: Medin drives Aβ40 to adopt Aβ42-like fibril polymorphs in vitro.
Authors: Pradhan B; Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium., Kumar ST; Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium., Wagner J; Biomedical Center (BMC), Biochemistry, Faculty of Medicine, LMU Munich, Munich, Germany., Gallardo R; Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium., Orlando G; Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium., De Vleeschouwer M; Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium., Madine J; Institute of Systems, Molecular & Integrative Biology, University of Liverpool, United Kingdom., Louros N; Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium., Neher JJ; Biomedical Center (BMC), Biochemistry, Faculty of Medicine, LMU Munich, Munich, Germany.; Neuroimmunology and Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Rousseau F; Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium., Schymkowitz J; Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Jul 20. Date of Electronic Publication: 2025 Jul 20.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.1101/2025.07.17.665283