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Medin drives Aβ40 to adopt Aβ42-like fibril polymorphs in vitro.

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Title: Medin drives Aβ40 to adopt Aβ42-like fibril polymorphs in vitro.
Authors: Pradhan B; Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium., Kumar ST; Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium., Wagner J; Biomedical Center (BMC), Biochemistry, Faculty of Medicine, LMU Munich, Munich, Germany., Gallardo R; Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium., Orlando G; Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium., De Vleeschouwer M; Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium., Madine J; Institute of Systems, Molecular & Integrative Biology, University of Liverpool, United Kingdom., Louros N; Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium., Neher JJ; Biomedical Center (BMC), Biochemistry, Faculty of Medicine, LMU Munich, Munich, Germany.; Neuroimmunology and Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Rousseau F; Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium., Schymkowitz J; Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Jul 20. Date of Electronic Publication: 2025 Jul 20.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Medin drives Aβ40 to adopt Aβ42-like fibril polymorphs in vitro.
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  Data: <searchLink fieldCode="AU" term="%22Pradhan+B%22">Pradhan B</searchLink>; Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Kumar+ST%22">Kumar ST</searchLink>; Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Wagner+J%22">Wagner J</searchLink>; Biomedical Center (BMC), Biochemistry, Faculty of Medicine, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Gallardo+R%22">Gallardo R</searchLink>; Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Orlando+G%22">Orlando G</searchLink>; Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Vleeschouwer+M%22">De Vleeschouwer M</searchLink>; Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Madine+J%22">Madine J</searchLink>; Institute of Systems, Molecular & Integrative Biology, University of Liverpool, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Louros+N%22">Louros N</searchLink>; Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Neher+JJ%22">Neher JJ</searchLink>; Biomedical Center (BMC), Biochemistry, Faculty of Medicine, LMU Munich, Munich, Germany.; Neuroimmunology and Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Rousseau+F%22">Rousseau F</searchLink>; Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Schymkowitz+J%22">Schymkowitz J</searchLink>; Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.
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              Text: 2025 Jul 20
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