CDK8 remodels the tumor microenvironment to resist the therapeutic efficacy of targeted KRAS G12D inhibition in pancreatic ductal adenocarcinoma.

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Title: CDK8 remodels the tumor microenvironment to resist the therapeutic efficacy of targeted KRAS G12D inhibition in pancreatic ductal adenocarcinoma.
Authors: McAndrews KM, Mahadevan KK, Li B, Sockwell AM, Morse SJ, Kelly PJ, Patel SI, Kirtley ML, Diaz BAM, Lyu H, Peng DH, Zhou X, Sugimoto H, Bickert AA, Sthanam LK, Conner MR, Kumbhar SV, Arian KA, Barekatain Y, Paradiso F, Guerrero PA, Bernard V, Sobhani N, Camacho-Acevedo AN, Bornes KE, Tran PT, Maitra A, Heffernan TP, Kalluri R
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Jul 15. Date of Electronic Publication: 2025 Jul 15.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Availability: 0
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DbLabel: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: CDK8 remodels the tumor microenvironment to resist the therapeutic efficacy of targeted KRAS <superscript>G12D</superscript> inhibition in pancreatic ductal adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22McAndrews+KM%22">McAndrews KM</searchLink><br /><searchLink fieldCode="AU" term="%22Mahadevan+KK%22">Mahadevan KK</searchLink><br /><searchLink fieldCode="AU" term="%22Li+B%22">Li B</searchLink><br /><searchLink fieldCode="AU" term="%22Sockwell+AM%22">Sockwell AM</searchLink><br /><searchLink fieldCode="AU" term="%22Morse+SJ%22">Morse SJ</searchLink><br /><searchLink fieldCode="AU" term="%22Kelly+PJ%22">Kelly PJ</searchLink><br /><searchLink fieldCode="AU" term="%22Patel+SI%22">Patel SI</searchLink><br /><searchLink fieldCode="AU" term="%22Kirtley+ML%22">Kirtley ML</searchLink><br /><searchLink fieldCode="AU" term="%22Diaz+BAM%22">Diaz BAM</searchLink><br /><searchLink fieldCode="AU" term="%22Lyu+H%22">Lyu H</searchLink><br /><searchLink fieldCode="AU" term="%22Peng+DH%22">Peng DH</searchLink><br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink><br /><searchLink fieldCode="AU" term="%22Sugimoto+H%22">Sugimoto H</searchLink><br /><searchLink fieldCode="AU" term="%22Bickert+AA%22">Bickert AA</searchLink><br /><searchLink fieldCode="AU" term="%22Sthanam+LK%22">Sthanam LK</searchLink><br /><searchLink fieldCode="AU" term="%22Conner+MR%22">Conner MR</searchLink><br /><searchLink fieldCode="AU" term="%22Kumbhar+SV%22">Kumbhar SV</searchLink><br /><searchLink fieldCode="AU" term="%22Arian+KA%22">Arian KA</searchLink><br /><searchLink fieldCode="AU" term="%22Barekatain+Y%22">Barekatain Y</searchLink><br /><searchLink fieldCode="AU" term="%22Paradiso+F%22">Paradiso F</searchLink><br /><searchLink fieldCode="AU" term="%22Guerrero+PA%22">Guerrero PA</searchLink><br /><searchLink fieldCode="AU" term="%22Bernard+V%22">Bernard V</searchLink><br /><searchLink fieldCode="AU" term="%22Sobhani+N%22">Sobhani N</searchLink><br /><searchLink fieldCode="AU" term="%22Camacho-Acevedo+AN%22">Camacho-Acevedo AN</searchLink><br /><searchLink fieldCode="AU" term="%22Bornes+KE%22">Bornes KE</searchLink><br /><searchLink fieldCode="AU" term="%22Tran+PT%22">Tran PT</searchLink><br /><searchLink fieldCode="AU" term="%22Maitra+A%22">Maitra A</searchLink><br /><searchLink fieldCode="AU" term="%22Heffernan+TP%22">Heffernan TP</searchLink><br /><searchLink fieldCode="AU" term="%22Kalluri+R%22">Kalluri R</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2025 Jul 15. <i>Date of Electronic Publication: </i>2025 Jul 15.
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1101/2025.01.29.635543
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              Text: 2025 Jul 15
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