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Downregulation of AdipoR1 in the hippocampus impairs synaptic function and structure and causes depression-like behavior.

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Title: Downregulation of AdipoR1 in the hippocampus impairs synaptic function and structure and causes depression-like behavior.
Authors: Zhu P; Department of Histology and Embryology, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China.; Laboratory of Stem Cells and Tissue Engineering, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China.; Department of Pathology, Hubei Provincial Hospital of Traditional Chinese Medicine, Hubei University of Chinese Medicine, Wuhan, Hubei, China., Luo Y; Laboratory of Stem Cells and Tissue Engineering, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China.; Department of Physiology, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China., Li Y; Department of Histology and Embryology, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China.; Laboratory of Stem Cells and Tissue Engineering, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China., Tang J; Department of Histology and Embryology, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China.; Laboratory of Stem Cells and Tissue Engineering, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China., Liu L; Department of Histology and Embryology, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China.; Laboratory of Stem Cells and Tissue Engineering, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China., Deng Y; Department of Histology and Embryology, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China.; Laboratory of Stem Cells and Tissue Engineering, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China., Li J; Department of Histology and Embryology, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China.; Laboratory of Stem Cells and Tissue Engineering, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China., Jiang L; Lab Teaching & Management Center, Chongqing Medical University, Chongqing, P. R. China., Yang W; Laboratory of Stem Cells and Tissue Engineering, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China.; Department of Physiology, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China., Xiao Q; Laboratory of Stem Cells and Tissue Engineering, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China.; Department of Radioactive Medicine, Chongqing Medical University, Chongqing, P. R. China., Wang S; Department of Histology and Embryology, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China.; Laboratory of Stem Cells and Tissue Engineering, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China., Zhou Y; Department of Histology and Embryology, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China.; Laboratory of Stem Cells and Tissue Engineering, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China., Chao F; Department of Histology and Embryology, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China.; Laboratory of Stem Cells and Tissue Engineering, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China., Zhang L; Department of Histology and Embryology, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China.; Laboratory of Stem Cells and Tissue Engineering, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China., Zhou C; Department of Histology and Embryology, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China.; Laboratory of Stem Cells and Tissue Engineering, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China., Tang Y; Department of Histology and Embryology, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China. ytang062@163.com.; Laboratory of Stem Cells and Tissue Engineering, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China. ytang062@163.com., Liang X; Laboratory of Stem Cells and Tissue Engineering, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China. liangxinjiayou@163.com.; Department of Pathology, School of Basic Medical Science, Chongqing Medical University, Chongqing, P. R. China. liangxinjiayou@163.com.
Source: Translational psychiatry [Transl Psychiatry] 2025 Aug 12; Vol. 15 (1), pp. 277. Date of Electronic Publication: 2025 Aug 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2158-3188
DOI:10.1038/s41398-025-03495-0