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A citrullinated histone H3 monoclonal antibody for immune modulation in sepsis.

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Title: A citrullinated histone H3 monoclonal antibody for immune modulation in sepsis.
Authors: Ouyang W; Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA.; Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Changsha, China., Chen Y; Division of Surgical Sciences, Department of Surgery, University of Virginia, Charlottesville, VA, USA., Tan T; Division of Surgical Sciences, Department of Surgery, University of Virginia, Charlottesville, VA, USA., Song Y; Department of Mechanical and Aerospace Engineering, NYU Tandon School of Engineering, Brooklyn, NY, USA.; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA., Dong T; Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA.; Department of Physiology, Xuzhou Medical University, Xuzhou, Jiangsu, China., Yu X; Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA.; Department of Emergency Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China., Lee KE; Division of Surgical Sciences, Department of Surgery, University of Virginia, Charlottesville, VA, USA., Zhou X; Division of Surgical Sciences, Department of Surgery, University of Virginia, Charlottesville, VA, USA., Tetz Z; Division of Surgical Sciences, Department of Surgery, University of Virginia, Charlottesville, VA, USA., Go S; Division of Surgical Sciences, Department of Surgery, University of Virginia, Charlottesville, VA, USA., Zeng X; Division of Surgical Sciences, Department of Surgery, University of Virginia, Charlottesville, VA, USA., Shao L; Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA., Quan C; Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA.; Department of Urology, The Xiangya Hospital, Changsha, China., Zhao T; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Tian Y; Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA.; Department of Rheumatology and Immunology, Xiangya Hospital, Changsha, China., Kurabayashi K; Department of Mechanical and Aerospace Engineering, NYU Tandon School of Engineering, Brooklyn, NY, USA.; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.; Department of Chemical and Biomolecular Engineering, New York University, Brooklyn, NY, USA., Jin H; SparX Biopharmaceutical Corp, Mount Prospect, IL, USA., Ma J; SparX Biopharmaceutical Corp, Mount Prospect, IL, USA., Qin J; SparX Biopharmaceutical Corp, Mount Prospect, IL, USA., Williams B; SparX Biopharmaceutical Corp, Mount Prospect, IL, USA., Li Q; SparX Biopharmaceutical Corp, Mount Prospect, IL, USA., Zhu GD; SparX Biopharmaceutical Corp, Mount Prospect, IL, USA., Alam HB; Department of Surgery, Northwestern University, Arkes Pavilion, Chicago, IL, USA., Stringer KA; Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA.; The Max Harry Weil Institute for Critical Care Research and Innovation, University of Michigan, Ann Arbor, MI, USA., Li Y; Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA. yqli@med.umich.edu., Ma J; Division of Surgical Sciences, Department of Surgery, University of Virginia, Charlottesville, VA, USA. Jianjie.ma@virginia.edu.
Source: Nature communications [Nat Commun] 2025 Aug 12; Vol. 16 (1), pp. 7435. Date of Electronic Publication: 2025 Aug 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: A citrullinated histone H3 monoclonal antibody for immune modulation in sepsis.
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  Data: <searchLink fieldCode="AU" term="%22Ouyang+W%22">Ouyang W</searchLink>; Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA.; Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Division of Surgical Sciences, Department of Surgery, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Tan+T%22">Tan T</searchLink>; Division of Surgical Sciences, Department of Surgery, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Song+Y%22">Song Y</searchLink>; Department of Mechanical and Aerospace Engineering, NYU Tandon School of Engineering, Brooklyn, NY, USA.; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Dong+T%22">Dong T</searchLink>; Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA.; Department of Physiology, Xuzhou Medical University, Xuzhou, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Yu+X%22">Yu X</searchLink>; Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA.; Department of Emergency Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Lee+KE%22">Lee KE</searchLink>; Division of Surgical Sciences, Department of Surgery, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; Division of Surgical Sciences, Department of Surgery, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Tetz+Z%22">Tetz Z</searchLink>; Division of Surgical Sciences, Department of Surgery, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Go+S%22">Go S</searchLink>; Division of Surgical Sciences, Department of Surgery, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Zeng+X%22">Zeng X</searchLink>; Division of Surgical Sciences, Department of Surgery, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Shao+L%22">Shao L</searchLink>; Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Quan+C%22">Quan C</searchLink>; Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA.; Department of Urology, The Xiangya Hospital, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Zhao+T%22">Zhao T</searchLink>; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tian+Y%22">Tian Y</searchLink>; Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA.; Department of Rheumatology and Immunology, Xiangya Hospital, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Kurabayashi+K%22">Kurabayashi K</searchLink>; Department of Mechanical and Aerospace Engineering, NYU Tandon School of Engineering, Brooklyn, NY, USA.; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.; Department of Chemical and Biomolecular Engineering, New York University, Brooklyn, NY, USA.<br /><searchLink fieldCode="AU" term="%22Jin+H%22">Jin H</searchLink>; SparX Biopharmaceutical Corp, Mount Prospect, IL, USA.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; SparX Biopharmaceutical Corp, Mount Prospect, IL, USA.<br /><searchLink fieldCode="AU" term="%22Qin+J%22">Qin J</searchLink>; SparX Biopharmaceutical Corp, Mount Prospect, IL, USA.<br /><searchLink fieldCode="AU" term="%22Williams+B%22">Williams B</searchLink>; SparX Biopharmaceutical Corp, Mount Prospect, IL, USA.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; SparX Biopharmaceutical Corp, Mount Prospect, IL, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+GD%22">Zhu GD</searchLink>; SparX Biopharmaceutical Corp, Mount Prospect, IL, USA.<br /><searchLink fieldCode="AU" term="%22Alam+HB%22">Alam HB</searchLink>; Department of Surgery, Northwestern University, Arkes Pavilion, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Stringer+KA%22">Stringer KA</searchLink>; Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA.; The Max Harry Weil Institute for Critical Care Research and Innovation, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA. yqli@med.umich.edu.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Division of Surgical Sciences, Department of Surgery, University of Virginia, Charlottesville, VA, USA. Jianjie.ma@virginia.edu.
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