View in EDS

PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer.

Saved in:
Bibliographic Details
Title: PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer.
Authors: Young AA; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA., Juhler IG; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA., Pierce JR; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA., Bohlin HE; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA., Harper HA; Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana 47907, USA., Onishile DS; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA., Chua RN; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA., Liu ME; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA., Gardner EN; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA., Elzey BD; Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana 47907, USA.; Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana 47907, USA., Cottrell KA; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA kacottre@purdue.edu.; Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana 47907, USA.
Source: RNA (New York, N.Y.) [RNA] 2025 Oct 16; Vol. 31 (11), pp. 1599-1618. Date of Electronic Publication: 2025 Oct 16.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9509184 Publication Model: Electronic Cited Medium: Internet ISSN: 1469-9001 (Electronic) Linking ISSN: 13558382 NLM ISO Abbreviation: RNA Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40803890
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Young+AA%22">Young AA</searchLink>; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA.<br /><searchLink fieldCode="AU" term="%22Juhler+IG%22">Juhler IG</searchLink>; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA.<br /><searchLink fieldCode="AU" term="%22Pierce+JR%22">Pierce JR</searchLink>; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA.<br /><searchLink fieldCode="AU" term="%22Bohlin+HE%22">Bohlin HE</searchLink>; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA.<br /><searchLink fieldCode="AU" term="%22Harper+HA%22">Harper HA</searchLink>; Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana 47907, USA.<br /><searchLink fieldCode="AU" term="%22Onishile+DS%22">Onishile DS</searchLink>; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA.<br /><searchLink fieldCode="AU" term="%22Chua+RN%22">Chua RN</searchLink>; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA.<br /><searchLink fieldCode="AU" term="%22Liu+ME%22">Liu ME</searchLink>; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA.<br /><searchLink fieldCode="AU" term="%22Gardner+EN%22">Gardner EN</searchLink>; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA.<br /><searchLink fieldCode="AU" term="%22Elzey+BD%22">Elzey BD</searchLink>; Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana 47907, USA.; Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana 47907, USA.<br /><searchLink fieldCode="AU" term="%22Cottrell+KA%22">Cottrell KA</searchLink>; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA kacottre@purdue.edu.; Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana 47907, USA.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229509184%22">RNA (New York, N.Y.)</searchLink> [RNA] 2025 Oct 16; Vol. 31 (11), pp. 1599-1618. <i>Date of Electronic Publication: </i>2025 Oct 16.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, N.I.H., Extramural
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cold+Spring+Harbor+Laboratory+Press%22">Cold Spring Harbor Laboratory Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9509184 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1469-9001 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213558382%22">13558382 </searchLink><i>NLM ISO Abbreviation: </i>RNA <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40803890
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1261/rna.080637.125
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 1599
    Titles:
      – TitleFull: PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Young AA
      – PersonEntity:
          Name:
            NameFull: Juhler IG
      – PersonEntity:
          Name:
            NameFull: Pierce JR
      – PersonEntity:
          Name:
            NameFull: Bohlin HE
      – PersonEntity:
          Name:
            NameFull: Harper HA
      – PersonEntity:
          Name:
            NameFull: Onishile DS
      – PersonEntity:
          Name:
            NameFull: Chua RN
      – PersonEntity:
          Name:
            NameFull: Liu ME
      – PersonEntity:
          Name:
            NameFull: Gardner EN
      – PersonEntity:
          Name:
            NameFull: Elzey BD
      – PersonEntity:
          Name:
            NameFull: Cottrell KA
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 16
              M: 10
              Text: 2025 Oct 16
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1469-9001
          Numbering:
            – Type: volume
              Value: 31
            – Type: issue
              Value: 11
          Titles:
            – TitleFull: RNA (New York, N.Y.)
              Type: main
ResultId 1