PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer.
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| Title: | PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer. |
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| Authors: | Young AA; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA., Juhler IG; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA., Pierce JR; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA., Bohlin HE; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA., Harper HA; Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana 47907, USA., Onishile DS; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA., Chua RN; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA., Liu ME; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA., Gardner EN; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA., Elzey BD; Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana 47907, USA.; Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana 47907, USA., Cottrell KA; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA kacottre@purdue.edu.; Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana 47907, USA. |
| Source: | RNA (New York, N.Y.) [RNA] 2025 Oct 16; Vol. 31 (11), pp. 1599-1618. Date of Electronic Publication: 2025 Oct 16. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9509184 Publication Model: Electronic Cited Medium: Internet ISSN: 1469-9001 (Electronic) Linking ISSN: 13558382 NLM ISO Abbreviation: RNA Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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