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Prostaglandin I2 signaling restrains Treg cell ST2 expression by repressing β-catenin in allergic airway inflammation.

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Title: Prostaglandin I2 signaling restrains Treg cell ST2 expression by repressing β-catenin in allergic airway inflammation.
Authors: Norlander AE; Department of Cell Biology, Anatomy, and Physiology, Indiana University School of Medicine, Indianapolis, Ind; Krannert Cardiovascular Research Center, Department of Medicine, Indiana University School of Medicine, Indianapolis, Ind; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tenn. Electronic address: aenorlan@iu.edu., Abney M; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tenn., Zhang J; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tenn., Polosukhin VV; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tenn., Thomas CM; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tenn., Ceneviva ZJ; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tenn., AlMotairy R; Department of Cell Biology, Anatomy, and Physiology, Indiana University School of Medicine, Indianapolis, Ind., Patel R; Department of Cell Biology, Anatomy, and Physiology, Indiana University School of Medicine, Indianapolis, Ind., Cephus JY; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tenn., Toki S; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tenn., Zhou W; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tenn., Chatila TA; Division of Immunology, Boston Children's Hospital, and the Department of Pediatrics, Harvard Medical School, Boston, Mass., Newcomb DC; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tenn; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tenn., Peebles RS Jr; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tenn; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tenn; United States Department of Veterans Affairs Medical Center, Nashville, Tenn.
Source: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2025 Dec; Vol. 156 (6), pp. 1679-1692.e9. Date of Electronic Publication: 2025 Aug 12.
Publication Type: Journal Article
Journal Info: Publisher: Mosby Country of Publication: United States NLM ID: 1275002 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6825 (Electronic) Linking ISSN: 00916749 NLM ISO Abbreviation: J Allergy Clin Immunol Subsets: MEDLINE
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  Data: Prostaglandin I<subscript>2</subscript> signaling restrains Treg cell ST2 expression by repressing β-catenin in allergic airway inflammation.
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  Data: <searchLink fieldCode="AU" term="%22Norlander+AE%22">Norlander AE</searchLink>; Department of Cell Biology, Anatomy, and Physiology, Indiana University School of Medicine, Indianapolis, Ind; Krannert Cardiovascular Research Center, Department of Medicine, Indiana University School of Medicine, Indianapolis, Ind; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tenn. Electronic address: aenorlan@iu.edu.<br /><searchLink fieldCode="AU" term="%22Abney+M%22">Abney M</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.<br /><searchLink fieldCode="AU" term="%22Polosukhin+VV%22">Polosukhin VV</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.<br /><searchLink fieldCode="AU" term="%22Thomas+CM%22">Thomas CM</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.<br /><searchLink fieldCode="AU" term="%22Ceneviva+ZJ%22">Ceneviva ZJ</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.<br /><searchLink fieldCode="AU" term="%22AlMotairy+R%22">AlMotairy R</searchLink>; Department of Cell Biology, Anatomy, and Physiology, Indiana University School of Medicine, Indianapolis, Ind.<br /><searchLink fieldCode="AU" term="%22Patel+R%22">Patel R</searchLink>; Department of Cell Biology, Anatomy, and Physiology, Indiana University School of Medicine, Indianapolis, Ind.<br /><searchLink fieldCode="AU" term="%22Cephus+JY%22">Cephus JY</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.<br /><searchLink fieldCode="AU" term="%22Toki+S%22">Toki S</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.<br /><searchLink fieldCode="AU" term="%22Zhou+W%22">Zhou W</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.<br /><searchLink fieldCode="AU" term="%22Chatila+TA%22">Chatila TA</searchLink>; Division of Immunology, Boston Children's Hospital, and the Department of Pediatrics, Harvard Medical School, Boston, Mass.<br /><searchLink fieldCode="AU" term="%22Newcomb+DC%22">Newcomb DC</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tenn; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tenn.<br /><searchLink fieldCode="AU" term="%22Peebles+RS+Jr%22">Peebles RS Jr</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tenn; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tenn; United States Department of Veterans Affairs Medical Center, Nashville, Tenn.
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        Value: 10.1016/j.jaci.2025.07.028
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              Text: 2025 Dec
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