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Multi-omics profiling reveals PLEKHA6 as a modulator of β-catenin signaling and therapeutic vulnerability in lung adenocarcinoma.

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Title: Multi-omics profiling reveals PLEKHA6 as a modulator of β-catenin signaling and therapeutic vulnerability in lung adenocarcinoma.
Authors: Su BH; School of Respiratory Therapy, College of Medicine, Taipei Medical University Taipei 11031, Taiwan., Kumar S; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University Taipei 11031, Taiwan.; Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences Himachal Pradesh 173229, India., Cheng LH; Core Laboratory of Organoids Technology, Office of R&D, Taipei Medical University Taipei 11031, Taiwan., Chang WJ; Division of Pulmonology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University Taipei 11031, Taiwan., Solomon DD; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University Taipei 11031, Taiwan.; Yogananda School of AI Computers and Data Sciences, Shoolini University Solan 173229, India., Ko CC; Department of Medical Imaging, Chi-Mei Medical Center Tainan 71004, Taiwan.; Department of Health and Nutrition, Chia Nan University of Pharmacy and Science Tainan 71710, Taiwan.; School of Medicine, College of Medicine, National Sun Yat-Sen University Kaohsiung 80424, Taiwan., Chiao CC; Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences Himachal Pradesh 173229, India.; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University Taipei 11031, Taiwan., Xuan DTM; Faculty of Pharmacy, Van Lang University 69/68 Dang Thuy Tram Street, Ward 13, Binh Thanh District, Ho Chi Minh 70000, Vietnam., Ngadio JL; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University Taipei 11031, Taiwan.; Department of Bioinformatics, School of Life Sciences, Indonesia International Institute for Life Sciences Jl Pulomas Barat Kav 88, Jakarta Timur 13210, Indonesia., Heryanto CM; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University Taipei 11031, Taiwan.; Department of Biotechnology, Faculty of Applied Sciences, UCSI University No. 1, Jalan UCSI, UCSI Heights, Cheras 56000, Kuala Lumpur, Malaysia., William BT; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University Taipei 11031, Taiwan.; Department of Biomedicine, School of Life Sciences, Indonesia International Institute for Life Sciences Jl Pulomas Barat Kav 88, Jakarta Timur 13210, Indonesia., Wulandari FS; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University Taipei 11031, Taiwan.; Department of Surgery, Division of Neurosurgery, Shuang Ho Hospital, Taipei Medical University New Taipei City 23561, Taiwan., Yang HC; Department of Surgery, Division of Neurosurgery, Shuang Ho Hospital, Taipei Medical University New Taipei City 23561, Taiwan., Lin HY; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University Taipei 11031, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University Taipei 11031, Taiwan.; Cancer Center, Wan Fang Hospital, Taipei Medical University Taipei 11031, Taiwan.; Traditional Herbal Medicine Research Center of Taipei Medical University Hospital, Taipei Medical University Taipei 11031, Taiwan.; Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences Rensselaer, NY 12144, USA., Wang CY; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University Taipei 11031, Taiwan.; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University Taipei 11031, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University Taipei 11031, Taiwan., Tsai MC; School of Medicine, Fu Jen Catholic University New Taipei City 242, Taiwan.; Department of Neurosurgery, Shin-Kong Wu Ho-Su Memorial Hospital 95 Wen-Chang Road, Shih-Lin District, Taipei 111045, Taiwan., Lai MD; Department of Biochemistry and Molecular Biology, National Cheng Kung University Tainan 70101, Taiwan.; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University Tainan 70101, Taiwan.
Source: American journal of cancer research [Am J Cancer Res] 2025 Jul 25; Vol. 15 (7), pp. 3106-3127. Date of Electronic Publication: 2025 Jul 25 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: e-Century Pub. Corp Country of Publication: United States NLM ID: 101549944 Publication Model: eCollection Cited Medium: Print ISSN: 2156-6976 (Print) Linking ISSN: 21566976 NLM ISO Abbreviation: Am J Cancer Res Subsets: PubMed not MEDLINE
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  Data: Multi-omics profiling reveals PLEKHA6 as a modulator of β-catenin signaling and therapeutic vulnerability in lung adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Su+BH%22">Su BH</searchLink>; School of Respiratory Therapy, College of Medicine, Taipei Medical University Taipei 11031, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kumar+S%22">Kumar S</searchLink>; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University Taipei 11031, Taiwan.; Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences Himachal Pradesh 173229, India.<br /><searchLink fieldCode="AU" term="%22Cheng+LH%22">Cheng LH</searchLink>; Core Laboratory of Organoids Technology, Office of R&D, Taipei Medical University Taipei 11031, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+WJ%22">Chang WJ</searchLink>; Division of Pulmonology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University Taipei 11031, Taiwan.<br /><searchLink fieldCode="AU" term="%22Solomon+DD%22">Solomon DD</searchLink>; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University Taipei 11031, Taiwan.; Yogananda School of AI Computers and Data Sciences, Shoolini University Solan 173229, India.<br /><searchLink fieldCode="AU" term="%22Ko+CC%22">Ko CC</searchLink>; Department of Medical Imaging, Chi-Mei Medical Center Tainan 71004, Taiwan.; Department of Health and Nutrition, Chia Nan University of Pharmacy and Science Tainan 71710, Taiwan.; School of Medicine, College of Medicine, National Sun Yat-Sen University Kaohsiung 80424, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiao+CC%22">Chiao CC</searchLink>; Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences Himachal Pradesh 173229, India.; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University Taipei 11031, Taiwan.<br /><searchLink fieldCode="AU" term="%22Xuan+DTM%22">Xuan DTM</searchLink>; Faculty of Pharmacy, Van Lang University 69/68 Dang Thuy Tram Street, Ward 13, Binh Thanh District, Ho Chi Minh 70000, Vietnam.<br /><searchLink fieldCode="AU" term="%22Ngadio+JL%22">Ngadio JL</searchLink>; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University Taipei 11031, Taiwan.; Department of Bioinformatics, School of Life Sciences, Indonesia International Institute for Life Sciences Jl Pulomas Barat Kav 88, Jakarta Timur 13210, Indonesia.<br /><searchLink fieldCode="AU" term="%22Heryanto+CM%22">Heryanto CM</searchLink>; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University Taipei 11031, Taiwan.; Department of Biotechnology, Faculty of Applied Sciences, UCSI University No. 1, Jalan UCSI, UCSI Heights, Cheras 56000, Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22William+BT%22">William BT</searchLink>; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University Taipei 11031, Taiwan.; Department of Biomedicine, School of Life Sciences, Indonesia International Institute for Life Sciences Jl Pulomas Barat Kav 88, Jakarta Timur 13210, Indonesia.<br /><searchLink fieldCode="AU" term="%22Wulandari+FS%22">Wulandari FS</searchLink>; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University Taipei 11031, Taiwan.; Department of Surgery, Division of Neurosurgery, Shuang Ho Hospital, Taipei Medical University New Taipei City 23561, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+HC%22">Yang HC</searchLink>; Department of Surgery, Division of Neurosurgery, Shuang Ho Hospital, Taipei Medical University New Taipei City 23561, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+HY%22">Lin HY</searchLink>; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University Taipei 11031, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University Taipei 11031, Taiwan.; Cancer Center, Wan Fang Hospital, Taipei Medical University Taipei 11031, Taiwan.; Traditional Herbal Medicine Research Center of Taipei Medical University Hospital, Taipei Medical University Taipei 11031, Taiwan.; Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences Rensselaer, NY 12144, USA.<br /><searchLink fieldCode="AU" term="%22Wang+CY%22">Wang CY</searchLink>; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University Taipei 11031, Taiwan.; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University Taipei 11031, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University Taipei 11031, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+MC%22">Tsai MC</searchLink>; School of Medicine, Fu Jen Catholic University New Taipei City 242, Taiwan.; Department of Neurosurgery, Shin-Kong Wu Ho-Su Memorial Hospital 95 Wen-Chang Road, Shih-Lin District, Taipei 111045, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lai+MD%22">Lai MD</searchLink>; Department of Biochemistry and Molecular Biology, National Cheng Kung University Tainan 70101, Taiwan.; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University Tainan 70101, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%22101549944%22">American journal of cancer research</searchLink> [Am J Cancer Res] 2025 Jul 25; Vol. 15 (7), pp. 3106-3127. <i>Date of Electronic Publication: </i>2025 Jul 25 (<i>Print Publication: </i>2025).
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        Value: 10.62347/NVVF8441
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              Text: 2025 Jul 25
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