Introduction of 1,3-diethyl-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-ylidene as new ligand for the design of antitumor-active (NHC)gold(I) complexes: An approach to reduce ligand scrambling and to increase tumor cell selectivity.
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| Title: | Introduction of 1,3-diethyl-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-ylidene as new ligand for the design of antitumor-active (NHC)gold(I) complexes: An approach to reduce ligand scrambling and to increase tumor cell selectivity. |
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| Authors: | Scherfler A; Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria., Schwaiger S; Department of Pharmacognosy, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria., Wurst K; Department of General, Inorganic, and Theoretical Chemistry, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria., Kircher B; Department of Internal Medicine V, Haematology & Oncology, Immunobiology and Stem Cell Laboratory, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria; Tyrolean Cancer Research Institute, Innrain 66, 6020 Innsbruck, Austria., Baecker D; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Freie Universität Berlin, Königin-Luise-Straße 2+4, 14195 Berlin, Germany. Electronic address: d.baecker@fu-berlin.de., Gust R; Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria. Electronic address: rgust@zedat.fu-berlin.de. |
| Source: | European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 05; Vol. 299, pp. 117919. Date of Electronic Publication: 2025 Jun 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40815902 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Introduction of 1,3-diethyl-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-ylidene as new ligand for the design of antitumor-active (NHC)gold(I) complexes: An approach to reduce ligand scrambling and to increase tumor cell selectivity. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Scherfler+A%22">Scherfler A</searchLink>; Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Schwaiger+S%22">Schwaiger S</searchLink>; Department of Pharmacognosy, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Wurst+K%22">Wurst K</searchLink>; Department of General, Inorganic, and Theoretical Chemistry, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Kircher+B%22">Kircher B</searchLink>; Department of Internal Medicine V, Haematology & Oncology, Immunobiology and Stem Cell Laboratory, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria; Tyrolean Cancer Research Institute, Innrain 66, 6020 Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Baecker+D%22">Baecker D</searchLink>; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Freie Universität Berlin, Königin-Luise-Straße 2+4, 14195 Berlin, Germany. Electronic address: d.baecker@fu-berlin.de.<br /><searchLink fieldCode="AU" term="%22Gust+R%22">Gust R</searchLink>; Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria. Electronic address: rgust@zedat.fu-berlin.de. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220420510%22">European journal of medicinal chemistry</searchLink> [Eur J Med Chem] 2025 Dec 05; Vol. 299, pp. 117919. <i>Date of Electronic Publication: </i>2025 Jun 30. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>0420510 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1768-3254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202235234%22">02235234 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Med Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40815902 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.ejmech.2025.117919 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 117919 Titles: – TitleFull: Introduction of 1,3-diethyl-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-ylidene as new ligand for the design of antitumor-active (NHC)gold(I) complexes: An approach to reduce ligand scrambling and to increase tumor cell selectivity. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Scherfler A – PersonEntity: Name: NameFull: Schwaiger S – PersonEntity: Name: NameFull: Wurst K – PersonEntity: Name: NameFull: Kircher B – PersonEntity: Name: NameFull: Baecker D – PersonEntity: Name: NameFull: Gust R IsPartOfRelationships: – BibEntity: Dates: – D: 05 M: 12 Text: 2025 Dec 05 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1768-3254 Numbering: – Type: volume Value: 299 Titles: – TitleFull: European journal of medicinal chemistry Type: main |
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