Lipidomic and proteomic insights from extracellular vesicles in the postmortem dorsolateral prefrontal cortex reveal substance use disorder-induced brain changes.

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Title: Lipidomic and proteomic insights from extracellular vesicles in the postmortem dorsolateral prefrontal cortex reveal substance use disorder-induced brain changes.
Authors: Okeoma CM; Department of Pathology, Microbiology & Immunology, New York Medical College, Valhalla, NY, USA. cokeoma@nymc.edu.; Lovelace Biomedical Institute, Albuquerque, NM, USA. cokeoma@nymc.edu., Naushad W; Department of Pathology, Microbiology & Immunology, New York Medical College, Valhalla, NY, USA., Okeoma BC; Department of Pathology, Microbiology & Immunology, New York Medical College, Valhalla, NY, USA., Gartner C; Maine Health Institute for Research, Scarborough, ME, USA., Santos-Ortega Y; Maine Health Institute for Research, Scarborough, ME, USA., Vary C; Maine Health Institute for Research, Scarborough, ME, USA.; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, USA., Lima-Bastos S; Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Carregari VC; Department of Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Larsen MR; Department of Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Noghero A; Lovelace Biomedical Institute, Albuquerque, NM, USA., Walss-Bass C; Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA. consuelo.walssbass@uth.tmc.edu., Grassi-Oliveira R; Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. rogo@clin.au.dk.; School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil. rogo@clin.au.dk.
Source: Translational psychiatry [Transl Psychiatry] 2025 Aug 15; Vol. 15 (1), pp. 284. Date of Electronic Publication: 2025 Aug 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2158-3188
DOI:10.1038/s41398-025-03512-2