SMAS: Structural MRI-based AD Score using Bayesian supervised VAE.

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Title: SMAS: Structural MRI-based AD Score using Bayesian supervised VAE.
Authors: Nemali A; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University (OVGU), Magdeburg, Germany; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany. Electronic address: aditya.nemali@dzne.de., Bernal J; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University (OVGU), Magdeburg, Germany; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany., Yakupov R; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University (OVGU), Magdeburg, Germany; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany., Singh D; DZNE, Rostock, Germany., Dyrba M; DZNE, Rostock, Germany., Incesoy EI; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University (OVGU), Magdeburg, Germany; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany; Department for Psychiatry and Psychotherapy, University Clinic Magdeburg, Germany., Mukherjee S; University of Bonn, Germany; University of Cambridge, Cambridge, UK; DZNE, Bonn, Germany., Peters O; DZNE, Berlin, Germany; Charité - Universitätsmedizin Berlin, Institute of Psychiatry and Psychotherapy, Berlin, Germany., Ersözlü E; DZNE, Berlin, Germany; Charité - Universitätsmedizin Berlin, Institute of Psychiatry and Psychotherapy, Berlin, Germany., Hellmann-Regen J; DZNE, Berlin, Germany; Charité - Universitätsmedizin Berlin, Institute of Psychiatry and Psychotherapy, Berlin, Germany., Preis L; Charité - Universitätsmedizin Berlin, Institute of Psychiatry and Psychotherapy, Berlin, Germany., Priller J; DZNE, Berlin, Germany; Charité - Universitätsmedizin Berlin, Institute of Psychiatry and Psychotherapy, Berlin, Germany; Technical University of Munich, Department of Psychiatry and Psychotherapy, Munich, Germany; University of Edinburgh, UK., Spruth E; DZNE, Berlin, Germany; Charité - Universitätsmedizin Berlin, Institute of Psychiatry and Psychotherapy, Berlin, Germany., Altenstein S; DZNE, Berlin, Germany; Charité - Universitätsmedizin Berlin, Institute of Psychiatry and Psychotherapy, Berlin, Germany., Lohse A; Charité - Universitätsmedizin Berlin, Institute of Psychiatry and Psychotherapy, Berlin, Germany., Schneider A; DZNE, Bonn, Germany; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Germany., Fliessbach K; DZNE, Bonn, Germany; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Germany., Kimmich O; DZNE, Bonn, Germany., Wiltfang J; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Germany; DZNE, Goettingen, Germany; Institute of Biomedicine (iBiMED), University of Aveiro, Portugal., Hansen N; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Germany., Schott B; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Germany; DZNE, Goettingen, Germany; Leibniz Institute for Neurobiology, Magdeburg, Germany., Rostamzadeh A; Department of Psychiatry, University of Cologne, Germany., Glanz W; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany; Department for Neurology, University Clinic Magdeburg, Germany., Butryn M; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany; Department for Neurology, University Clinic Magdeburg, Germany., Buerger K; DZNE, Munich, Germany; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Germany., Janowitz D; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Germany., Ewers M; DZNE, Munich, Germany; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Germany., Perneczky R; DZNE, Munich, Germany; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; Ageing Epidemiology Research Unit (AGE), Imperial College London, UK., Rauchmann B; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, UK; Department of Neuroradiology, University Hospital, LMU Munich, Germany., Teipel S; DZNE, Rostock, Germany; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany., Kilimann I; DZNE, Rostock, Germany; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany., Goerss D; DZNE, Rostock, Germany; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany., Laske C; DZNE, Tübingen, Germany; Section for Dementia Research, Hertie Institute for Clinical Brain Research, Germany; Department of Psychiatry and Psychotherapy, University of Tübingen, Germany., Sodenkamp S; DZNE, Tübingen, Germany; Department of Psychiatry and Psychotherapy, University of Tübingen, Germany., Spottke A; DZNE, Bonn, Germany; Department of Neurology, University of Bonn, Germany., Coenjaerts M; DZNE, Bonn, Germany., Brosseron F; DZNE, Bonn, Germany; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Germany., Lüsebrink F; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany., Dechent P; MR-Research in Neurosciences, Department of Cognitive Neurology, Georg-August-University Goettingen, Germany., Scheffler K; Department for Biomedical Magnetic Resonance, University of Tübingen, Germany., Hetzer S; Berlin Center for Advanced Neuroimaging, Charité - Universitätsmedizin Berlin, Germany., Kleineidam L; DZNE, Bonn, Germany; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Germany., Stark M; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Germany., Jessen F; DZNE, Bonn, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Germany; Department of Psychiatry, University of Cologne, Medical Faculty, Germany., Duzel E; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University (OVGU), Magdeburg, Germany; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany., Ziegler G; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University (OVGU), Magdeburg, Germany; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
Source: Computers in biology and medicine [Comput Biol Med] 2025 Sep; Vol. 196 (Pt C), pp. 110829. Date of Electronic Publication: 2025 Aug 15.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1250250 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0534 (Electronic) Linking ISSN: 00104825 NLM ISO Abbreviation: Comput Biol Med Subsets: MEDLINE
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  Data: SMAS: Structural MRI-based AD Score using Bayesian supervised VAE.
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  Data: <searchLink fieldCode="AU" term="%22Nemali+A%22">Nemali A</searchLink>; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University (OVGU), Magdeburg, Germany; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany. Electronic address: aditya.nemali@dzne.de.<br /><searchLink fieldCode="AU" term="%22Bernal+J%22">Bernal J</searchLink>; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University (OVGU), Magdeburg, Germany; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Yakupov+R%22">Yakupov R</searchLink>; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University (OVGU), Magdeburg, Germany; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Singh+D%22">Singh D</searchLink>; DZNE, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Dyrba+M%22">Dyrba M</searchLink>; DZNE, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Incesoy+EI%22">Incesoy EI</searchLink>; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University (OVGU), Magdeburg, Germany; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany; Department for Psychiatry and Psychotherapy, University Clinic Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Mukherjee+S%22">Mukherjee S</searchLink>; University of Bonn, Germany; University of Cambridge, Cambridge, UK; DZNE, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Peters+O%22">Peters O</searchLink>; DZNE, Berlin, Germany; Charité - Universitätsmedizin Berlin, Institute of Psychiatry and Psychotherapy, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Ersözlü+E%22">Ersözlü E</searchLink>; DZNE, Berlin, Germany; Charité - Universitätsmedizin Berlin, Institute of Psychiatry and Psychotherapy, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Hellmann-Regen+J%22">Hellmann-Regen J</searchLink>; DZNE, Berlin, Germany; Charité - Universitätsmedizin Berlin, Institute of Psychiatry and Psychotherapy, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Preis+L%22">Preis L</searchLink>; Charité - Universitätsmedizin Berlin, Institute of Psychiatry and Psychotherapy, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Priller+J%22">Priller J</searchLink>; DZNE, Berlin, Germany; Charité - Universitätsmedizin Berlin, Institute of Psychiatry and Psychotherapy, Berlin, Germany; Technical University of Munich, Department of Psychiatry and Psychotherapy, Munich, Germany; University of Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Spruth+E%22">Spruth E</searchLink>; DZNE, Berlin, Germany; Charité - Universitätsmedizin Berlin, Institute of Psychiatry and Psychotherapy, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Altenstein+S%22">Altenstein S</searchLink>; DZNE, Berlin, Germany; Charité - Universitätsmedizin Berlin, Institute of Psychiatry and Psychotherapy, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Lohse+A%22">Lohse A</searchLink>; Charité - Universitätsmedizin Berlin, Institute of Psychiatry and Psychotherapy, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Schneider+A%22">Schneider A</searchLink>; DZNE, Bonn, Germany; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Fliessbach+K%22">Fliessbach K</searchLink>; DZNE, Bonn, Germany; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Kimmich+O%22">Kimmich O</searchLink>; DZNE, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Wiltfang+J%22">Wiltfang J</searchLink>; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Germany; DZNE, Goettingen, Germany; Institute of Biomedicine (iBiMED), University of Aveiro, Portugal.<br /><searchLink fieldCode="AU" term="%22Hansen+N%22">Hansen N</searchLink>; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Germany.<br /><searchLink fieldCode="AU" term="%22Schott+B%22">Schott B</searchLink>; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Germany; DZNE, Goettingen, Germany; Leibniz Institute for Neurobiology, Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rostamzadeh+A%22">Rostamzadeh A</searchLink>; 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DZNE, Munich, Germany; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; Ageing Epidemiology Research Unit (AGE), Imperial College London, UK.<br /><searchLink fieldCode="AU" term="%22Rauchmann+B%22">Rauchmann B</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, UK; Department of Neuroradiology, University Hospital, LMU Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Teipel+S%22">Teipel S</searchLink>; DZNE, Rostock, Germany; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Kilimann+I%22">Kilimann I</searchLink>; DZNE, Rostock, Germany; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Goerss+D%22">Goerss D</searchLink>; 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