Safety and immunogenicity of novel live attenuated type 1 and type 3 oral poliomyelitis vaccines in healthy adults in the USA: a first-in-human, observer-masked, multicentre, phase 1 randomised controlled trial.

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Title: Safety and immunogenicity of novel live attenuated type 1 and type 3 oral poliomyelitis vaccines in healthy adults in the USA: a first-in-human, observer-masked, multicentre, phase 1 randomised controlled trial.
Authors: Mercer LD; Center for Vaccine Innovation and Access, PATH, Seattle, WA, USA., Seña AC; University of North Carolina at Chapel Hill, Institute for Global Health and Infectious Diseases, Chapel Hill, NC, USA., Colgate ER; The Vaccine Testing Center, Department of Microbiology and Molecular Genetics, University of Vermont Larner College of Medicine, Burlington, VT, USA., Crothers JW; The Vaccine Testing Center, Department of Microbiology and Molecular Genetics, University of Vermont Larner College of Medicine, Burlington, VT, USA; Department of Pathology and Laboratory Medicine, University of Vermont Larner College of Medicine, Burlington, VT, USA., Wright PF; Geisel School of Medicine, Dartmouth, Hanover, NH, USA., Al-Ibrahim M; Pharmaron CPC, Baltimore, MD, USA., Tritama E; PT Bio Farma, Bandung, Indonesia., Vincent A; Polio and Picornavirus Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA., Mainou BA; Polio and Picornavirus Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA., Zhang Y; Polio and Picornavirus Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA., Konopka-Anstadt J; Center for Vaccine Innovation and Access, PATH, Seattle, WA, USA., Bandyopadhyay AS; Bill & Melinda Gates Foundation, Seattle, WA, USA., Fix A; Center for Vaccine Innovation and Access, PATH, Seattle, WA, USA., Konz JO; Center for Vaccine Innovation and Access, PATH, Seattle, WA, USA., Gast C; Center for Vaccine Innovation and Access, PATH, Seattle, WA, USA. Electronic address: cgast@path.org.
Source: The Lancet. Infectious diseases [Lancet Infect Dis] 2025 Dec; Vol. 25 (12), pp. 1363-1376. Date of Electronic Publication: 2025 Aug 13.
Publication Type: Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 101130150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-4457 (Electronic) Linking ISSN: 14733099 NLM ISO Abbreviation: Lancet Infect Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1474-4457
DOI:10.1016/S1473-3099(25)00285-3