Platelets mediate neutrophil infiltration and exacerbate liver injury and sinusoidal endothelial cell damage after a severe acetaminophen overdose in mice.

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Title: Platelets mediate neutrophil infiltration and exacerbate liver injury and sinusoidal endothelial cell damage after a severe acetaminophen overdose in mice.
Authors: Adelusi OB; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS, 66160, USA., Schneider C; Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, USA.; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA.; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA., McKimens C; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS, 66160, USA., Luyendyk JP; Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, USA.; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA.; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA., Ramachandran A; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS, 66160, USA., Jaeschke H; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS, 66160, USA. hjaeschke@kumc.edu.
Source: Archives of toxicology [Arch Toxicol] 2025 Nov; Vol. 99 (11), pp. 4575-4594. Date of Electronic Publication: 2025 Aug 16.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Platelets mediate neutrophil infiltration and exacerbate liver injury and sinusoidal endothelial cell damage after a severe acetaminophen overdose in mice.
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  Data: <searchLink fieldCode="AU" term="%22Adelusi+OB%22">Adelusi OB</searchLink>; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS, 66160, USA.<br /><searchLink fieldCode="AU" term="%22Schneider+C%22">Schneider C</searchLink>; Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, USA.; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA.; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA.<br /><searchLink fieldCode="AU" term="%22McKimens+C%22">McKimens C</searchLink>; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS, 66160, USA.<br /><searchLink fieldCode="AU" term="%22Luyendyk+JP%22">Luyendyk JP</searchLink>; Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, USA.; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA.; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA.<br /><searchLink fieldCode="AU" term="%22Ramachandran+A%22">Ramachandran A</searchLink>; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS, 66160, USA.<br /><searchLink fieldCode="AU" term="%22Jaeschke+H%22">Jaeschke H</searchLink>; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS, 66160, USA. hjaeschke@kumc.edu.
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        Value: 10.1007/s00204-025-04144-7
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        Text: English
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      – TitleFull: Platelets mediate neutrophil infiltration and exacerbate liver injury and sinusoidal endothelial cell damage after a severe acetaminophen overdose in mice.
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              Text: 2025 Nov
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