Platelets mediate neutrophil infiltration and exacerbate liver injury and sinusoidal endothelial cell damage after a severe acetaminophen overdose in mice.

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Bibliographic Details
Title: Platelets mediate neutrophil infiltration and exacerbate liver injury and sinusoidal endothelial cell damage after a severe acetaminophen overdose in mice.
Authors: Adelusi OB; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS, 66160, USA., Schneider C; Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, USA.; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA.; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA., McKimens C; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS, 66160, USA., Luyendyk JP; Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, USA.; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA.; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA., Ramachandran A; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS, 66160, USA., Jaeschke H; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS, 66160, USA. hjaeschke@kumc.edu.
Source: Archives of toxicology [Arch Toxicol] 2025 Nov; Vol. 99 (11), pp. 4575-4594. Date of Electronic Publication: 2025 Aug 16.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-0738
DOI:10.1007/s00204-025-04144-7