Circulating genomic landscape following cyclin-dependent kinase 4/6 inhibitors exposure in HR + /HER2- metastatic breast cancer: a retrospective multi-institutional Consortium analysis.

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Title: Circulating genomic landscape following cyclin-dependent kinase 4/6 inhibitors exposure in HR + /HER2- metastatic breast cancer: a retrospective multi-institutional Consortium analysis.
Authors: Pontolillo L; Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, USA. lep4008@med.cornell.edu.; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy. lep4008@med.cornell.edu., Davis AA; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Gerratana L; Department of Medical Oncology, CRO Aviano National Cancer Institute, IRCCS, Aviano, Italy.; Department of Medicine, University of Udine, Via Chiusaforte, Udine, Italy., Medford AJ; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Wang J; Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, USA., Nicolo' E; Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, USA., Clifton K; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Velimirovic M; Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH, USA., Warrior S; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, USA., Podany E; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Andreopoulou E; Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, USA., Serafini MS; Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, USA., Munoz-Arcos L; Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, USA., Molteni E; Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, USA.; Department of Medicine, University of Udine, Via Chiusaforte, Udine, Italy., Lipsyc-Sharf M; David Geffen School of Medicine at UCLA, Los Angeles, USA., Gianni C; Medical Oncology, Breast & GYN Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., Bayou N; Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, USA.; Human Genetics Laboratory (LR99ES10), Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia., Dai CS; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Giannarelli D; Facility of Epidemiology and Biostatistics, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Bria E; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.; Medical Oncology, Ospedale Isola Tiberina-Gemelli Isola, Rome, Italy., Ma CX; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Bardia A; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.; David Geffen School of Medicine at UCLA, Los Angeles, USA., Reduzzi C; Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, USA., Cristofanilli M; Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, USA.
Source: NPJ breast cancer [NPJ Breast Cancer] 2025 Aug 16; Vol. 11 (1), pp. 93. Date of Electronic Publication: 2025 Aug 16.
Publication Type: Journal Article
Journal Info: Publisher: Breast Cancer Research Foundation Country of Publication: United States NLM ID: 101674891 Publication Model: Electronic Cited Medium: Print ISSN: 2374-4677 (Print) Linking ISSN: 23744677 NLM ISO Abbreviation: NPJ Breast Cancer Subsets: PubMed not MEDLINE
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  Data: Circulating genomic landscape following cyclin-dependent kinase 4/6 inhibitors exposure in HR + /HER2- metastatic breast cancer: a retrospective multi-institutional Consortium analysis.
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  Data: <searchLink fieldCode="AU" term="%22Pontolillo+L%22">Pontolillo L</searchLink>; Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, USA. lep4008@med.cornell.edu.; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy. lep4008@med.cornell.edu.<br /><searchLink fieldCode="AU" term="%22Davis+AA%22">Davis AA</searchLink>; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Gerratana+L%22">Gerratana L</searchLink>; Department of Medical Oncology, CRO Aviano National Cancer Institute, IRCCS, Aviano, Italy.; Department of Medicine, University of Udine, Via Chiusaforte, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Medford+AJ%22">Medford AJ</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Nicolo'+E%22">Nicolo' E</searchLink>; Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Clifton+K%22">Clifton K</searchLink>; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Velimirovic+M%22">Velimirovic M</searchLink>; Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Warrior+S%22">Warrior S</searchLink>; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Podany+E%22">Podany E</searchLink>; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Andreopoulou+E%22">Andreopoulou E</searchLink>; Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Serafini+MS%22">Serafini MS</searchLink>; Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Munoz-Arcos+L%22">Munoz-Arcos L</searchLink>; Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Molteni+E%22">Molteni E</searchLink>; Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, USA.; Department of Medicine, University of Udine, Via Chiusaforte, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Lipsyc-Sharf+M%22">Lipsyc-Sharf M</searchLink>; David Geffen School of Medicine at UCLA, Los Angeles, USA.<br /><searchLink fieldCode="AU" term="%22Gianni+C%22">Gianni C</searchLink>; Medical Oncology, Breast & GYN Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy.<br /><searchLink fieldCode="AU" term="%22Bayou+N%22">Bayou N</searchLink>; Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, USA.; Human Genetics Laboratory (LR99ES10), Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.<br /><searchLink fieldCode="AU" term="%22Dai+CS%22">Dai CS</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Giannarelli+D%22">Giannarelli D</searchLink>; Facility of Epidemiology and Biostatistics, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Bria+E%22">Bria E</searchLink>; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.; Medical Oncology, Ospedale Isola Tiberina-Gemelli Isola, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ma+CX%22">Ma CX</searchLink>; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Bardia+A%22">Bardia A</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.; David Geffen School of Medicine at UCLA, Los Angeles, USA.<br /><searchLink fieldCode="AU" term="%22Reduzzi+C%22">Reduzzi C</searchLink>; Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cristofanilli+M%22">Cristofanilli M</searchLink>; Division of Hematology-Oncology, Weill Cornell Medicine, New York, NY, USA.
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