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Randomized phase I trial outcomes show safe and sustainable inhibition of classical and lectin complement pathways by empasiprubart.

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Title: Randomized phase I trial outcomes show safe and sustainable inhibition of classical and lectin complement pathways by empasiprubart.
Authors: Van de Walle I; argenx, Ghent, Belgium. IVandeWalle@argenx.com., Bracke L; argenx, Ghent, Belgium., Olesen HG; Department of Molecular Biology and Genetics - Protein Science, Universitetsbyen 81, 8000, Aarhus C, Denmark., van Bragt T; Curare Consulting BV, Liempde, The Netherlands., Cadour S; argenx, Ghent, Belgium., De Decker P; argenx, Ghent, Belgium., Ciurlia G; argenx, Ghent, Belgium., Pannecoucke E; argenx, Ghent, Belgium., Persson EK; argenx, Ghent, Belgium., Van de Steen O; argenx, Ghent, Belgium., Leng X; argenx, Ghent, Belgium., Andersen GR; Department of Molecular Biology and Genetics - Protein Science, Universitetsbyen 81, 8000, Aarhus C, Denmark., Gandini D; argenx, Ghent, Belgium., Hack CE; argenx, Ghent, Belgium.
Source: Nature communications [Nat Commun] 2025 Aug 16; Vol. 16 (1), pp. 7639. Date of Electronic Publication: 2025 Aug 16.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Randomized phase I trial outcomes show safe and sustainable inhibition of classical and lectin complement pathways by empasiprubart.
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  Data: <searchLink fieldCode="AU" term="%22Van+de+Walle+I%22">Van de Walle I</searchLink>; argenx, Ghent, Belgium. IVandeWalle@argenx.com.<br /><searchLink fieldCode="AU" term="%22Bracke+L%22">Bracke L</searchLink>; argenx, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Olesen+HG%22">Olesen HG</searchLink>; Department of Molecular Biology and Genetics - Protein Science, Universitetsbyen 81, 8000, Aarhus C, Denmark.<br /><searchLink fieldCode="AU" term="%22van+Bragt+T%22">van Bragt T</searchLink>; Curare Consulting BV, Liempde, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Cadour+S%22">Cadour S</searchLink>; argenx, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Decker+P%22">De Decker P</searchLink>; argenx, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Ciurlia+G%22">Ciurlia G</searchLink>; argenx, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Pannecoucke+E%22">Pannecoucke E</searchLink>; argenx, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Persson+EK%22">Persson EK</searchLink>; argenx, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Van+de+Steen+O%22">Van de Steen O</searchLink>; argenx, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Leng+X%22">Leng X</searchLink>; argenx, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Andersen+GR%22">Andersen GR</searchLink>; Department of Molecular Biology and Genetics - Protein Science, Universitetsbyen 81, 8000, Aarhus C, Denmark.<br /><searchLink fieldCode="AU" term="%22Gandini+D%22">Gandini D</searchLink>; argenx, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Hack+CE%22">Hack CE</searchLink>; argenx, Ghent, Belgium.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Aug 16; Vol. 16 (1), pp. 7639. <i>Date of Electronic Publication: </i>2025 Aug 16.
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  Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40819168
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