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Leveraging multiomic approaches to elucidate mechanisms of heterogeneity in Alzheimer's disease: Neuropsychiatric symptoms, co-pathologies, and sex differences.

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Title: Leveraging multiomic approaches to elucidate mechanisms of heterogeneity in Alzheimer's disease: Neuropsychiatric symptoms, co-pathologies, and sex differences.
Authors: Shwab EK; Division of Translational Brain Sciences, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.; Center for Genomic and Computational Biology, Duke University Medical Center, Durham, North Carolina, USA., Pathak GA; Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Harvey J; Department of Clinical and Biomedical Sciences, University of Exeter Medical School, University of Exeter, Exeter, UK., Belloy ME; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.; Neurogenomics and Informatics Center, Washington University in St. Louis, School of Medicine, St. Louis, Missouri, USA., Fischer CE; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada., Lutz MW; Division of Translational Brain Sciences, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA., Scholz SW; Neurodegenerative Diseases Research Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, Maryland, USA., Cook N; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.; Neurogenomics and Informatics Center, Washington University in St. Louis, School of Medicine, St. Louis, Missouri, USA., Reid DM; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.; Neurogenomics and Informatics Center, Washington University in St. Louis, School of Medicine, St. Louis, Missouri, USA., Chen J; Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, Nevada, USA.; School of Life Science, University of Nevada, Las Vegas, Nevada, USA.; Interdisciplinary Neuroscience Program, University of Nevada, Las Vegas, Nevada, USA., Guan DX; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Oliveira F; Department of Neurology and Neurosurgery, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), São Paulo, Brazil., Sinclair LI; Translational Dementia Research Group, Faculty of Health Sciences, University of Bristol, Southmead Hospital, Bristol, UK., Imo U; College of Medicine, University of Ibadan, Oyo, Nigeria., Creese B; Department of Psychology, College of Health Medicine and Life Sciences, Brunel University of London, London, UK., Chiba-Falek O; Division of Translational Brain Sciences, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.; Center for Genomic and Computational Biology, Duke University Medical Center, Durham, North Carolina, USA.
Corporate Authors: Neuropsychiatric Syndromes Professional Interest Area Multiomics Work Group, Alzheimer's Association, International Society to Advance Alzheimer's Research and Treatment, Chicago, Illinois, USA
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Aug; Vol. 21 (8), pp. e70549.
Publication Type: Journal Article; Review
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Shwab+EK%22">Shwab EK</searchLink>; Division of Translational Brain Sciences, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.; Center for Genomic and Computational Biology, Duke University Medical Center, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Pathak+GA%22">Pathak GA</searchLink>; Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Harvey+J%22">Harvey J</searchLink>; Department of Clinical and Biomedical Sciences, University of Exeter Medical School, University of Exeter, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Belloy+ME%22">Belloy ME</searchLink>; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.; Neurogenomics and Informatics Center, Washington University in St. Louis, School of Medicine, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Fischer+CE%22">Fischer CE</searchLink>; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Lutz+MW%22">Lutz MW</searchLink>; Division of Translational Brain Sciences, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Scholz+SW%22">Scholz SW</searchLink>; Neurodegenerative Diseases Research Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Cook+N%22">Cook N</searchLink>; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.; Neurogenomics and Informatics Center, Washington University in St. Louis, School of Medicine, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Reid+DM%22">Reid DM</searchLink>; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.; Neurogenomics and Informatics Center, Washington University in St. Louis, School of Medicine, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, Nevada, USA.; School of Life Science, University of Nevada, Las Vegas, Nevada, USA.; Interdisciplinary Neuroscience Program, University of Nevada, Las Vegas, Nevada, USA.<br /><searchLink fieldCode="AU" term="%22Guan+DX%22">Guan DX</searchLink>; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Oliveira+F%22">Oliveira F</searchLink>; Department of Neurology and Neurosurgery, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Sinclair+LI%22">Sinclair LI</searchLink>; Translational Dementia Research Group, Faculty of Health Sciences, University of Bristol, Southmead Hospital, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Imo+U%22">Imo U</searchLink>; College of Medicine, University of Ibadan, Oyo, Nigeria.<br /><searchLink fieldCode="AU" term="%22Creese+B%22">Creese B</searchLink>; Department of Psychology, College of Health Medicine and Life Sciences, Brunel University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Chiba-Falek+O%22">Chiba-Falek O</searchLink>; Division of Translational Brain Sciences, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA.; Center for Genomic and Computational Biology, Duke University Medical Center, Durham, North Carolina, USA.
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